Reflectance spectroscopy for in vivo characterization of ovarian tissue

Urs Utzinger, Molly Brewer, Elvio Silva, David Gershenson, Robert C. Blast, Michele Follen, Rebecca Richards-Kortum

Research output: Contribution to journalArticlepeer-review

89 Scopus citations

Abstract

Background and Objective: To explore whether reflectance spectroscopy can differentiate normal ovary, benign neoplasms, and ovarian cancer. Study Design/Materials and Methods: Reflectance spectra (390-600 nm) were measured at three source-detector separations (SDS) in vivo at 64 sites in 16 patients undergoing oophorectomy. Parameters with largest statistical differences were identified. Based on these parameters algorithms were developed and evaluated. Results: Promising parameters were the reflectance intensity from 540 to 580 nm (SDS, 1.1 mm), the slope of the reflectance spectrum from 490 to 520 nm (SDS, 1.1 mm), the slope from 510 to 530 nm (SDS, 2.1 mm), and the slope from 510 to 530 (SDS, 3 mm). Average sensitivity and specificity were 86 ± 6% and 79 ± 5% to separate normal ovary from benign neoplasms and cancers. Average sensitivity and specificity were 86 ± 4% and 80 ± 8% to separate ovarian cancers from benign neoplasms and normal ovary. Conclusion: Reflectance spectroscopy should be further investigated for ovarian cancer screening. 2001 Wiley-Liss, Inc.

Original languageEnglish (US)
Pages (from-to)56-66
Number of pages11
JournalLasers in Surgery and Medicine
Volume28
Issue number1
DOIs
StatePublished - 2001
Externally publishedYes

Keywords

  • Ovarian cancer detection
  • Reflectance spectroscopy

ASJC Scopus subject areas

  • Surgery
  • Dermatology

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