Refractory disseminated coccidioidomycosis and mycobacteriosis in interferon-γ receptor 1 deficiency

Donald C. Vinh, Fares Masannat, Robert B. Dzioba, John N. Galgiani, Steven M. Holland

Research output: Contribution to journalArticle

80 Scopus citations

Abstract

Severe coccidioidomycosis is rare, and specific genetic susceptibility to the disease remains unidentified. We describe a patient with disseminated recalcitrant coccidioidomycosis with autosomal dominant interferon-γ receptor 1 deficiency caused by a heterozygous IFNGR1 818del4 mutation. Therefore, the interleukin-12/interferon-γ axis appears to be critical for control of coccidioidomycosis.

Original languageEnglish (US)
Pages (from-to)e62-e65
JournalClinical Infectious Diseases
Volume49
Issue number6
DOIs
StatePublished - Sep 15 2009

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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