Refractory disseminated coccidioidomycosis and mycobacteriosis in interferon-γ receptor 1 deficiency

Donald C. Vinh, Fares Masannat, Robert B. Dzioba, John N Galgiani, Steven M. Holland

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Severe coccidioidomycosis is rare, and specific genetic susceptibility to the disease remains unidentified. We describe a patient with disseminated recalcitrant coccidioidomycosis with autosomal dominant interferon-γ receptor 1 deficiency caused by a heterozygous IFNGR1 818del4 mutation. Therefore, the interleukin-12/interferon-γ axis appears to be critical for control of coccidioidomycosis.

Original languageEnglish (US)
JournalClinical Infectious Diseases
Volume49
Issue number6
DOIs
StatePublished - Sep 15 2009

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Interferon Receptors
Coccidioidomycosis
Genetic Predisposition to Disease
Interleukin-12
Interferons
Mutation

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)

Cite this

Refractory disseminated coccidioidomycosis and mycobacteriosis in interferon-γ receptor 1 deficiency. / Vinh, Donald C.; Masannat, Fares; Dzioba, Robert B.; Galgiani, John N; Holland, Steven M.

In: Clinical Infectious Diseases, Vol. 49, No. 6, 15.09.2009.

Research output: Contribution to journalArticle

Vinh, Donald C. ; Masannat, Fares ; Dzioba, Robert B. ; Galgiani, John N ; Holland, Steven M. / Refractory disseminated coccidioidomycosis and mycobacteriosis in interferon-γ receptor 1 deficiency. In: Clinical Infectious Diseases. 2009 ; Vol. 49, No. 6.
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