Regional dependence of morphine-induced μ-opiate receptor down-regulation in perinatal rat brain

Ronald P. Hammer, Joruel V. Seatriz, Arleen R. Ricalde

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

The effect of perinatal morphine administration was examined in various brain regions using in vitro receptor autoradiography. Morphine was administered by continuous s.c. infusion of 10 mg/kg per day; brains of offspring were examined at five days of age. Morphine exposure reduced μ-receptor binding density in the preoptic area of hypothalamus, but not in the primary somatosensory cortex. μ-Receptor density was greater in the medial preoptic area of females than males, and in superficial layers of cortex in males than females. The results suggest that morphine has selective regional effects on μ-receptor ontogeny in rat brain.

Original languageEnglish (US)
Pages (from-to)253-256
Number of pages4
JournalEuropean Journal of Pharmacology
Volume209
Issue number3
DOIs
StatePublished - Dec 17 1991
Externally publishedYes

Keywords

  • Developement
  • Hypothalamus
  • Opiates
  • [H]DAGO binding

ASJC Scopus subject areas

  • Pharmacology

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