Regional glucose metabolic abnormalities are not the result of atrophy in Alzheimer's disease

V. Ibáñez, P. Pietrini, Gene E Alexander, M. L. Furey, D. Teichberg, J. C. Rajapakse, S. I. Rapoport, M. B. Schapiro, B. Horwitz

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Abstract

Objective: To determine whether the hypometabolism observed in PET images of patients with Alzheimer's disease (AID) is due entirely to brain atrophy. Background: Reduced brain glucose metabolism in AD patients measured using PET has been reported by numerous authors. Actual glucose metabolic values in AD may be reduced artificially because of brain atrophy, which accentuates the partial volume effect (PVE) on data collected by PET. Methods: Using segmented MR images, we corrected regional cerebral metabolic rates for glucose for PVEs to evaluate the effect of atrophy on uncorrected values for brain metabolism in AD patients and healthy control subjects. Results: Global glucose metabolism was reduced significantly before and after correction in AD patients compared with controls. Before PVE correction, glucose metabolic values in patients were lower than in control subjects in the inferior parietal, frontal, and lateral temporal cortex; in the posterior cingulate; and in the precuneus. These reductions remained significantly lower after PVE correction, although in the posterior cingulate the difference in metabolism between AD patients and control subjects lessened. Regional glucose metabolism of these areas with PVE correction was lower in moderately-severely demented patients than in mildly demented patients. Conclusion: Reduced glucose metabolism measured by PET in AD is not simply an artifact due to an increase in CSF space induced by atrophy, but reflects a true metabolic reduction per gram of tissue.

Original languageEnglish (US)
Pages (from-to)1585-1593
Number of pages9
JournalNeurology
Volume50
Issue number6
StatePublished - Jun 1998
Externally publishedYes

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Atrophy
Alzheimer Disease
Glucose
Gyrus Cinguli
Brain
Parietal Lobe
Temporal Lobe
Artifacts
Healthy Volunteers

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Ibáñez, V., Pietrini, P., Alexander, G. E., Furey, M. L., Teichberg, D., Rajapakse, J. C., ... Horwitz, B. (1998). Regional glucose metabolic abnormalities are not the result of atrophy in Alzheimer's disease. Neurology, 50(6), 1585-1593.

Regional glucose metabolic abnormalities are not the result of atrophy in Alzheimer's disease. / Ibáñez, V.; Pietrini, P.; Alexander, Gene E; Furey, M. L.; Teichberg, D.; Rajapakse, J. C.; Rapoport, S. I.; Schapiro, M. B.; Horwitz, B.

In: Neurology, Vol. 50, No. 6, 06.1998, p. 1585-1593.

Research output: Contribution to journalArticle

Ibáñez, V, Pietrini, P, Alexander, GE, Furey, ML, Teichberg, D, Rajapakse, JC, Rapoport, SI, Schapiro, MB & Horwitz, B 1998, 'Regional glucose metabolic abnormalities are not the result of atrophy in Alzheimer's disease', Neurology, vol. 50, no. 6, pp. 1585-1593.
Ibáñez V, Pietrini P, Alexander GE, Furey ML, Teichberg D, Rajapakse JC et al. Regional glucose metabolic abnormalities are not the result of atrophy in Alzheimer's disease. Neurology. 1998 Jun;50(6):1585-1593.
Ibáñez, V. ; Pietrini, P. ; Alexander, Gene E ; Furey, M. L. ; Teichberg, D. ; Rajapakse, J. C. ; Rapoport, S. I. ; Schapiro, M. B. ; Horwitz, B. / Regional glucose metabolic abnormalities are not the result of atrophy in Alzheimer's disease. In: Neurology. 1998 ; Vol. 50, No. 6. pp. 1585-1593.
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