Regional mapping of the human platelet-activating factor receptor gene (PTAFR) to 1p35→p34.3 by fluorescence in situ hybridization

P. B. Chase, J. M. Yang, F. H. Thompson, M. Halonen, John W Regan

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The human platelet-activating factor cell-surface receptor (PTAFR) is a G protein-coupled receptor thought to contribute to many atopic and inflammatory diseases and, perhaps, to the growth of some neoplasms. Exploring the possibility that the PTAFR might be involved in the genetic predisposition to any disease requires knowledge of its chromosomal localization. In this paper we have used a 20-kb human genomic fragment containing the coding sequence of the cloned PTAFR to determine the regional chromosomal localization of the gene. Using fluorescence in situ hybridization, the localization of the human PTAFR gene was mapped to 1p35→p34.3.

Original languageEnglish (US)
Pages (from-to)205-207
Number of pages3
JournalCytogenetics and Cell Genetics
Volume72
Issue number2-3
StatePublished - 1996

Fingerprint

Fluorescence In Situ Hybridization
Genes
Platelet Activating Factor
Cell Surface Receptors
Genetic Predisposition to Disease
G-Protein-Coupled Receptors
platelet activating factor receptor
Growth
Neoplasms

ASJC Scopus subject areas

  • Genetics
  • Cell Biology

Cite this

Regional mapping of the human platelet-activating factor receptor gene (PTAFR) to 1p35→p34.3 by fluorescence in situ hybridization. / Chase, P. B.; Yang, J. M.; Thompson, F. H.; Halonen, M.; Regan, John W.

In: Cytogenetics and Cell Genetics, Vol. 72, No. 2-3, 1996, p. 205-207.

Research output: Contribution to journalArticle

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