Regional myocardial perfusion at rest and during intracoronary papaverine in patients with coronary artery disease

Steven Goldman, Robert Henry, Theron Ovitt, Mark J Friedman, Alan Rosenfeld, Michael Daly

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Regional myocardial perfusion was measured in 32 patients with the xenon-133 washout technique at rest and after 5 mg of intracoronary papaverine. Areas of decreased perfusion and/or decreased vasodilation were identified visually from computer-generated functional images. The locations of arteries and stenoses, obtained from identically positioned cineangiograms, were overlaid on the functional images. Perfusion rates for 62 myocardial regions were calculated and correlated with the percentage of stenosis. There was no association between degree of stenosis and perfusion at rest. Regional myocardial perfusion increased after papaverine in regions supplied by coronary arteries without stenoses (0% to 25%), 88.6 ± 4.7 ml/min/100 gm. This increase was significantly greater (p < 0.001) than the increase in regions supplied by 51% to 75% stenoses (23.7 ± 6.3 ml/min/100 gm), or 76% to 99% stenoses (12.9 ± 6.3 ml/min/100 gm), or 100% stenoses (2.5 ± 3.8 ml/min/100 gm). Thus there was an inverse relationship between the increase in myocardial perfusion stimulated by papaverine and the degree of coronary artery stenosis measured angiographically. In regions supplied by two stenoses in series, vasodilation produced less of an increase than a single stenosis of a similar degree.

Original languageEnglish (US)
Pages (from-to)372-379
Number of pages8
JournalAmerican Heart Journal
Volume105
Issue number3
DOIs
StatePublished - 1983

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Papaverine
Coronary Artery Disease
Pathologic Constriction
Perfusion
Coronary Stenosis
Vasodilation
Xenon
Arteries

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Regional myocardial perfusion at rest and during intracoronary papaverine in patients with coronary artery disease. / Goldman, Steven; Henry, Robert; Ovitt, Theron; Friedman, Mark J; Rosenfeld, Alan; Daly, Michael.

In: American Heart Journal, Vol. 105, No. 3, 1983, p. 372-379.

Research output: Contribution to journalArticle

Goldman, Steven ; Henry, Robert ; Ovitt, Theron ; Friedman, Mark J ; Rosenfeld, Alan ; Daly, Michael. / Regional myocardial perfusion at rest and during intracoronary papaverine in patients with coronary artery disease. In: American Heart Journal. 1983 ; Vol. 105, No. 3. pp. 372-379.
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