Regional pattern of hippocampus and corpus callosum atrophy in Alzheimer's disease in relation to dementia severity: Evidence for early neocortical degeneration

S. J. Teipel, W. Bayer, G. E. Alexander, A. L.W. Bokde, Y. Zebuhr, D. Teichberg, F. Müller-Spahn, M. B. Schapiro, H. J. Möller, S. I. Rapoport, H. Hampel

Research output: Contribution to journalArticle

80 Scopus citations

Abstract

We used volumetric MRI and analysis of areas under receiver operating characteristic (ROC) curves to directly compare the extent of hippocampus-amygdala formation (HAF) and corpus callosum atrophy in patients with Alzheimer's disease (AD) in different clinical stages of dementia. Based on neuropathological studies, we hypothesized that HAF atrophy, representing allocortical neuronal degeneration, would precede atrophy of corpus callosum, representing loss of neocortical association neurons, in early AD. HAF and corpus callosum sizes were significantly reduced in 27 AD patients (37% and 16%, respectively) compared to 28 healthy controls. In mildly- and moderately-demented AD patients, the ROC derived index of atrophy was greater for HAF volume than for total corpus callosum area. The index of atrophy of posterior corpus callosum was not significantly different from HAF at mild, moderate or severe stages of dementia. In conclusion, these findings suggest a characteristic regional pattern of allocortical and neocortical neurodegeneraton in AD. Our data indicate that neuronal loss in parietotemporal cortex (represented by atrophy of corpus callosum splenium) may occur simultaneously with allocortical neurodegeneration in mild AD. Moreover, ROC analysis may provide a statistical framework to determine atrophy patterns of different brain structures in neurodegenerative diseases in vivo.

Original languageEnglish (US)
Pages (from-to)85-94
Number of pages10
JournalNeurobiology of Aging
Volume24
Issue number1
DOIs
StatePublished - Jan 1 2003

Keywords

  • Allocortex
  • Alzheimer's disease
  • Amygdala
  • Brain atrophy
  • Clinical stages
  • Corpus callosum
  • Disease progression
  • Hippocampus
  • Magnetic resonance imaging
  • Neocortex
  • Neurodegeneration
  • ROC

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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    Teipel, S. J., Bayer, W., Alexander, G. E., Bokde, A. L. W., Zebuhr, Y., Teichberg, D., Müller-Spahn, F., Schapiro, M. B., Möller, H. J., Rapoport, S. I., & Hampel, H. (2003). Regional pattern of hippocampus and corpus callosum atrophy in Alzheimer's disease in relation to dementia severity: Evidence for early neocortical degeneration. Neurobiology of Aging, 24(1), 85-94. https://doi.org/10.1016/S0197-4580(02)00044-1