Regions of acquired uniparental disomy at diagnosis of follicular lymphoma are associated with both overall survival and risk of transformation

Derville O'Shea, Ciaran O'Riain, Manu Gupta, Rachel Waters, Youwen Yang, David Wrench, John Gribben, Andreas Rosenwald, German Ott, Lisa M Rimsza, Harald Holte, Jean Baptiste Cazier, Nathalie A. Johnson, Elias Campo, Wing C. Chan, Randy D. Gascoyne, Bryan D. Young, Louis M. Staudt, T. Andrew Lister, Jude Fitzgibbon

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Abstract

Acquired homozygosity in the form of segmental acquired uniparental disomy (aUPD) has been described in follicular lymphoma (FL) and is usually due to mitotic recombination. SNP array analysis was performed with the use of the Affymetrix 10K 2.0 Gene-chip array on DNA from 185 diagnostic FL patients to assess theprognosticrelevanceofaUPD. Genetic abnormalities were detected in 118 (65%) of 182 patients. Number of abnormalities was predictive of outcome; more than 3 abnormalities was associated with inferior overall survival (OS; P <.03). Sites of recurrent aUPD were detected on 6p (n = 25), 16p (n = 22), 12q (n = 17), 1p36 (n = 14), 10q (n = 8), and 6q (n = 8). On multivariate analysis aUPD on 1p36 correlated with shorter OS (P =.05). aUPD on 16p was predictive of transformation (P =.03) and correlated with poorer progression-free survival (P =.02). aUPD is frequent at diagnosis of FL and affects probability of disease transformation and clinical outcome. (Blood. 2009;113:2298-2301)

Original languageEnglish (US)
Pages (from-to)2298-2301
Number of pages4
JournalBlood
Volume113
Issue number10
DOIs
StatePublished - Mar 5 2009

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Uniparental Disomy
Follicular Lymphoma
Blood
Genes
Survival
DNA
Oligonucleotide Array Sequence Analysis
Genetic Recombination
Disease-Free Survival
Single Nucleotide Polymorphism
Multivariate Analysis

ASJC Scopus subject areas

  • Hematology
  • Biochemistry
  • Cell Biology
  • Immunology

Cite this

Regions of acquired uniparental disomy at diagnosis of follicular lymphoma are associated with both overall survival and risk of transformation. / O'Shea, Derville; O'Riain, Ciaran; Gupta, Manu; Waters, Rachel; Yang, Youwen; Wrench, David; Gribben, John; Rosenwald, Andreas; Ott, German; Rimsza, Lisa M; Holte, Harald; Cazier, Jean Baptiste; Johnson, Nathalie A.; Campo, Elias; Chan, Wing C.; Gascoyne, Randy D.; Young, Bryan D.; Staudt, Louis M.; Lister, T. Andrew; Fitzgibbon, Jude.

In: Blood, Vol. 113, No. 10, 05.03.2009, p. 2298-2301.

Research output: Contribution to journalArticle

O'Shea, D, O'Riain, C, Gupta, M, Waters, R, Yang, Y, Wrench, D, Gribben, J, Rosenwald, A, Ott, G, Rimsza, LM, Holte, H, Cazier, JB, Johnson, NA, Campo, E, Chan, WC, Gascoyne, RD, Young, BD, Staudt, LM, Lister, TA & Fitzgibbon, J 2009, 'Regions of acquired uniparental disomy at diagnosis of follicular lymphoma are associated with both overall survival and risk of transformation', Blood, vol. 113, no. 10, pp. 2298-2301. https://doi.org/10.1182/blood-2008-08-174953
O'Shea, Derville ; O'Riain, Ciaran ; Gupta, Manu ; Waters, Rachel ; Yang, Youwen ; Wrench, David ; Gribben, John ; Rosenwald, Andreas ; Ott, German ; Rimsza, Lisa M ; Holte, Harald ; Cazier, Jean Baptiste ; Johnson, Nathalie A. ; Campo, Elias ; Chan, Wing C. ; Gascoyne, Randy D. ; Young, Bryan D. ; Staudt, Louis M. ; Lister, T. Andrew ; Fitzgibbon, Jude. / Regions of acquired uniparental disomy at diagnosis of follicular lymphoma are associated with both overall survival and risk of transformation. In: Blood. 2009 ; Vol. 113, No. 10. pp. 2298-2301.
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abstract = "Acquired homozygosity in the form of segmental acquired uniparental disomy (aUPD) has been described in follicular lymphoma (FL) and is usually due to mitotic recombination. SNP array analysis was performed with the use of the Affymetrix 10K 2.0 Gene-chip array on DNA from 185 diagnostic FL patients to assess theprognosticrelevanceofaUPD. Genetic abnormalities were detected in 118 (65{\%}) of 182 patients. Number of abnormalities was predictive of outcome; more than 3 abnormalities was associated with inferior overall survival (OS; P <.03). Sites of recurrent aUPD were detected on 6p (n = 25), 16p (n = 22), 12q (n = 17), 1p36 (n = 14), 10q (n = 8), and 6q (n = 8). On multivariate analysis aUPD on 1p36 correlated with shorter OS (P =.05). aUPD on 16p was predictive of transformation (P =.03) and correlated with poorer progression-free survival (P =.02). aUPD is frequent at diagnosis of FL and affects probability of disease transformation and clinical outcome. (Blood. 2009;113:2298-2301)",
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T1 - Regions of acquired uniparental disomy at diagnosis of follicular lymphoma are associated with both overall survival and risk of transformation

AU - O'Shea, Derville

AU - O'Riain, Ciaran

AU - Gupta, Manu

AU - Waters, Rachel

AU - Yang, Youwen

AU - Wrench, David

AU - Gribben, John

AU - Rosenwald, Andreas

AU - Ott, German

AU - Rimsza, Lisa M

AU - Holte, Harald

AU - Cazier, Jean Baptiste

AU - Johnson, Nathalie A.

AU - Campo, Elias

AU - Chan, Wing C.

AU - Gascoyne, Randy D.

AU - Young, Bryan D.

AU - Staudt, Louis M.

AU - Lister, T. Andrew

AU - Fitzgibbon, Jude

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N2 - Acquired homozygosity in the form of segmental acquired uniparental disomy (aUPD) has been described in follicular lymphoma (FL) and is usually due to mitotic recombination. SNP array analysis was performed with the use of the Affymetrix 10K 2.0 Gene-chip array on DNA from 185 diagnostic FL patients to assess theprognosticrelevanceofaUPD. Genetic abnormalities were detected in 118 (65%) of 182 patients. Number of abnormalities was predictive of outcome; more than 3 abnormalities was associated with inferior overall survival (OS; P <.03). Sites of recurrent aUPD were detected on 6p (n = 25), 16p (n = 22), 12q (n = 17), 1p36 (n = 14), 10q (n = 8), and 6q (n = 8). On multivariate analysis aUPD on 1p36 correlated with shorter OS (P =.05). aUPD on 16p was predictive of transformation (P =.03) and correlated with poorer progression-free survival (P =.02). aUPD is frequent at diagnosis of FL and affects probability of disease transformation and clinical outcome. (Blood. 2009;113:2298-2301)

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