Regioselective ring metalation in [2,4]-bisoxazoles

David R. Williams, Dawn A. Brooks, Kevin G. Meyer, Mark "Marty" Pagel

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The efficient, highly regioselective metalation of a 2,4-disubstituted bisoxazole system is described. The resulting lithio-oxazole is a competent nucleophile in subsequent alkylations.

Original languageEnglish (US)
Pages (from-to)8023-8026
Number of pages4
JournalTetrahedron Letters
Volume39
Issue number44
StatePublished - Oct 29 1998
Externally publishedYes

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Oxazoles
Nucleophiles
Alkylation

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Williams, D. R., Brooks, D. A., Meyer, K. G., & Pagel, M. M. (1998). Regioselective ring metalation in [2,4]-bisoxazoles. Tetrahedron Letters, 39(44), 8023-8026.

Regioselective ring metalation in [2,4]-bisoxazoles. / Williams, David R.; Brooks, Dawn A.; Meyer, Kevin G.; Pagel, Mark "Marty".

In: Tetrahedron Letters, Vol. 39, No. 44, 29.10.1998, p. 8023-8026.

Research output: Contribution to journalArticle

Williams, DR, Brooks, DA, Meyer, KG & Pagel, MM 1998, 'Regioselective ring metalation in [2,4]-bisoxazoles', Tetrahedron Letters, vol. 39, no. 44, pp. 8023-8026.
Williams DR, Brooks DA, Meyer KG, Pagel MM. Regioselective ring metalation in [2,4]-bisoxazoles. Tetrahedron Letters. 1998 Oct 29;39(44):8023-8026.
Williams, David R. ; Brooks, Dawn A. ; Meyer, Kevin G. ; Pagel, Mark "Marty". / Regioselective ring metalation in [2,4]-bisoxazoles. In: Tetrahedron Letters. 1998 ; Vol. 39, No. 44. pp. 8023-8026.
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