Registration of on-board X-ray images with 4DCT: A proposed method of phase and setup verification for gated radiotherapy

Qianyi Xu, Zhijun He, Jiajin Fan, Russell J Hamilton, Yan Chen, C. M. Ma, Lei Xing

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Current gated radiation therapy starts with simulation 4DCT images of a patient with lung cancer. We propose a method to confirm the phase of 4DCT for planning and setup position at the time of treatment. An intensity-based rigid algorithm was developed in this work to register an orthogonal set of on-board projection X-ray images with each phase of the 4DCT. Multiple DRRs for one of ten 4DCT phases are first generated and the correlation coefficient (CC) between the projection X-ray image and each DRR is computed. The maximum value of CC for the phase is found via a simulated annealing optimization process. The whole process repeats for all ten phases. The 4DCT phase that has the highest CC is identified as the breathing phase of the X-ray. The phase verification process is validated by a moving phantom study. Thus, the method may be used to independently confirm the correspondence between the gating phase at the times of 4DCT simulation and radiotherapy delivery. When the intended X-ray phase and actual gating phase are consistent, the registration of the DRRs and the projection images may also yield the values of patient shifts for treatment setup. This method could serve as the 4D analog of the conventional setup film as it provides both verification of the specific phase at the time of treatment and isocenter positioning shifts for treatment delivery.

Original languageEnglish (US)
Pages (from-to)117-125
Number of pages9
JournalPhysica Medica
Volume26
Issue number3
DOIs
StatePublished - 2010

Fingerprint

radiation therapy
Radiotherapy
X-Rays
correlation coefficients
projection
delivery
x rays
shift
registers
simulated annealing
Therapeutics
breathing
lungs
positioning
planning
Lung Neoplasms
Respiration
simulation
cancer
analogs

Keywords

  • 4DCT
  • Registration
  • Setup verification

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging
  • Physics and Astronomy(all)
  • Medicine(all)

Cite this

Registration of on-board X-ray images with 4DCT : A proposed method of phase and setup verification for gated radiotherapy. / Xu, Qianyi; He, Zhijun; Fan, Jiajin; Hamilton, Russell J; Chen, Yan; Ma, C. M.; Xing, Lei.

In: Physica Medica, Vol. 26, No. 3, 2010, p. 117-125.

Research output: Contribution to journalArticle

Xu, Qianyi ; He, Zhijun ; Fan, Jiajin ; Hamilton, Russell J ; Chen, Yan ; Ma, C. M. ; Xing, Lei. / Registration of on-board X-ray images with 4DCT : A proposed method of phase and setup verification for gated radiotherapy. In: Physica Medica. 2010 ; Vol. 26, No. 3. pp. 117-125.
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