Regression and data mining methods for analyses of multiple rare variants in the Genetic Analysis Workshop 17 mini-exome data

Joan E. Bailey-Wilson, Jennifer S. Brennan, Shelley B. Bull, Robert Culverhouse, Yoonhee Kim, Yuan Jiang, Jeesun Jung, Qing Li, Claudia Lamina, Ying Liu, Reedik Mägi, Yue S. Niu, Claire L. Simpson, Libo Wang, Yildiz E. Yilmaz, Heping Zhang, Zhaogong Zhang

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Group 14 of Genetic Analysis Workshop 17 examined several issues related to analysis of complex traits using DNA sequence data. These issues included novel methods for analyzing rare genetic variants in an aggregated manner (often termed collapsing rare variants), evaluation of various study designs to increase power to detect effects of rare variants, and the use of machine learning approaches to model highly complex heterogeneous traits. Various published and novel methods for analyzing traits with extreme locus and allelic heterogeneity were applied to the simulated quantitative and disease phenotypes. Overall, we conclude that power is (as expected) dependent on locus-specific heritability or contribution to disease risk, large samples will be required to detect rare causal variants with small effect sizes, extreme phenotype sampling designs may increase power for smaller laboratory costs, methods that allow joint analysis of multiple variants per gene or pathway are more powerful in general than analyses of individual rare variants, population-specific analyses can be optimal when different subpopulations harbor private causal mutations, and machine learning methods may be useful for selecting subsets of predictors for follow-up in the presence of extreme locus heterogeneity and large numbers of potential predictors.

Original languageEnglish (US)
Pages (from-to)S92-S100
JournalGenetic Epidemiology
Volume35
Issue numberSUPPL. 1
DOIs
StatePublished - Dec 5 2011

Keywords

  • Binary trees
  • Classification trees
  • Extreme sampling
  • ISIS
  • LASSO
  • Logic regression
  • Machine learning
  • Meta-analysis
  • Poisson regression
  • Random forests
  • Rare variants

ASJC Scopus subject areas

  • Epidemiology
  • Genetics(clinical)

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    Bailey-Wilson, J. E., Brennan, J. S., Bull, S. B., Culverhouse, R., Kim, Y., Jiang, Y., Jung, J., Li, Q., Lamina, C., Liu, Y., Mägi, R., Niu, Y. S., Simpson, C. L., Wang, L., Yilmaz, Y. E., Zhang, H., & Zhang, Z. (2011). Regression and data mining methods for analyses of multiple rare variants in the Genetic Analysis Workshop 17 mini-exome data. Genetic Epidemiology, 35(SUPPL. 1), S92-S100. https://doi.org/10.1002/gepi.20657