Regression of aggressive laryngeal papillomatosis with 13-cis-retinoic acid (accutane)

David S. Alberts, Stanley W. Coulthard, Frank L. Meyskens

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Laryngeal papillomatosis often involves a relentless growth of papillomas on the vocal cords, requiring repeated excisions to maintain an adequate airway. Because of its antiproliferative effects on epithelial tissues, 13-cis-retinoic acid (0.5-2.0 mg/kd/day p.o.) was used in five patients whose disease was poorly controlled by laser beam surgery. Control of disease for 24 +, 5 +, and 12 months has been achieved in three of the patients, with two complete and one partial responses. Side effects of treatment were mild and rapidly reversible, following a 25-50% reduction in drug dose.

Original languageEnglish (US)
Pages (from-to)124-128
Number of pages5
JournalJournal of Biological Response Modifiers
Issue number2
StatePublished - Apr 1986


  • Accutane
  • Laryngeal papillomatosis
  • Polypoid lesions
  • Vocal cords

ASJC Scopus subject areas

  • Immunology
  • Pharmacology
  • Cancer Research


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