Regulation of anti-Sm autoantibodies by the immunoglobulin heavy chain locus

M. D. Halpern, S. Y. Craven, P. L. Cohen, R. A. Eisenberg

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Anti-Sm antibodies are specific markers for systemic lupus erythematosus in MRL mice and in humans. The prevalence of anti-Sm positivity in inbred MRL/Mp-lpr/lpr(MRL/lpr) mice is consistently about 25% at 5 mo of age, when the disease is at its peak. The control of the development of anti-Sm in individual MRL/lpr mice has been shown to be the result of stochastic factors, and previous research has indicated that the immunoglobulin heavy chain (IgH) b allotype may be more amenable to the production of anti-Sm. We have now further investigated the influence of the IgH genetic locus on the production of anti-Sm and other autoantibodies in an allotype congenic MRL strain, the MRL/Mp-lpr/lpr-IgHb (MRL/lpr-IgHb). Strikingly, 78% of MRL/lpr- IgHb mice produced anti-Sm, compared with 27% of contemporaneous MRL/lpr (IgH(j)) mice. Of those mice that were positive for anti-Sm, the MRL/lpr- IgHb strain produced significantly higher levels of anti-Sm than did the anti-Sm positive MRL/lpr mice. No differences were observed between the conventional MRL/lpr and the MRL/lpr-IgHb levels of antichromatin, anti- ssDNA, antiribosomal P, or anti-Su. In addition, kidney function, which was assessed by measuring serum urea nitrogen levels, was similar in the two strains. These results support the notion that the control of anti-Sm production in MRL/lpr mice operates through the IgH locus.

Original languageEnglish (US)
Pages (from-to)7268-7272
Number of pages5
JournalJournal of Immunology
Volume151
Issue number12
StatePublished - Jan 1 1993
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Halpern, M. D., Craven, S. Y., Cohen, P. L., & Eisenberg, R. A. (1993). Regulation of anti-Sm autoantibodies by the immunoglobulin heavy chain locus. Journal of Immunology, 151(12), 7268-7272.