Regulation of antibiotic production: Catabolite inhibition and the dualistic effect of glucose on indolmycin production

Laurence H. Hurley, Donald Bialek

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The production of the antibiotic, indolmycin, was shown to be inhibited by glucose at 0.5%. Concentrations of glucose of 0.005% and 0.01% produced a stimulation of indolmycin production. Of a selection of mono and disaccharides examined, glucose and to a lesser extent mannose, caused inhibition of indolmycin production. Galactose, fructose and sucrose all caused stimulation of indolmycin synthesis.

Original languageEnglish (US)
Pages (from-to)49-56
Number of pages8
JournalThe Journal of Antibiotics
Volume27
Issue number1
DOIs
StatePublished - Jan 1 1974
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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