Regulation of drug metabolism and toxicity by multiple factors of genetics, epigenetics, lncRNAs, gut microbiota, and diseases

a meeting report of the 21st International Symposium on Microsomes and Drug Oxidations (MDO)

Ai Ming Yu, Magnus Ingelman-Sundberg, Nathan J Cherrington, Lauren M. Aleksunes, Ulrich M. Zanger, Wen Xie, Hyunyoung Jeong, Edward M. Morgan, Peter J. Turnbaugh, Curtis D. Klaassen, Aadra P. Bhatt, Matthew R. Redinbo, Pengying Hao, David J. Waxman, Li Wang, Xiao bo Zhong

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Variations in drug metabolism may alter drug efficacy and cause toxicity; better understanding of the mechanisms and risks shall help to practice precision medicine. At the 21st International Symposium on Microsomes and Drug Oxidations held in Davis, California, USA, in October 2–6, 2016, a number of speakers reported some new findings and ongoing studies on the regulation mechanisms behind variable drug metabolism and toxicity, and discussed potential implications to personalized medications. A considerably insightful overview was provided on genetic and epigenetic regulation of gene expression involved in drug absorption, distribution, metabolism, and excretion (ADME) and drug response. Altered drug metabolism and disposition as well as molecular mechanisms among diseased and special populations were presented. In addition, the roles of gut microbiota in drug metabolism and toxicology as well as long non-coding RNAs in liver functions and diseases were discussed. These findings may offer new insights into improved understanding of ADME regulatory mechanisms and advance drug metabolism research.

Original languageEnglish (US)
Pages (from-to)241-248
Number of pages8
JournalActa Pharmaceutica Sinica B
Volume7
Issue number2
DOIs
StatePublished - Mar 1 2017

Fingerprint

Long Noncoding RNA
Microsomes
Drug-Related Side Effects and Adverse Reactions
Epigenomics
Pharmaceutical Preparations
Precision Medicine
Gastrointestinal Microbiome
Gene Expression Regulation
Toxicology
Liver Diseases

Keywords

  • Disease
  • Drug metabolism and toxicity
  • Epigenetics
  • Genetics
  • Gut microbiota
  • Long non-coding RNAs
  • Personalized medication

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Regulation of drug metabolism and toxicity by multiple factors of genetics, epigenetics, lncRNAs, gut microbiota, and diseases : a meeting report of the 21st International Symposium on Microsomes and Drug Oxidations (MDO). / Yu, Ai Ming; Ingelman-Sundberg, Magnus; Cherrington, Nathan J; Aleksunes, Lauren M.; Zanger, Ulrich M.; Xie, Wen; Jeong, Hyunyoung; Morgan, Edward M.; Turnbaugh, Peter J.; Klaassen, Curtis D.; Bhatt, Aadra P.; Redinbo, Matthew R.; Hao, Pengying; Waxman, David J.; Wang, Li; Zhong, Xiao bo.

In: Acta Pharmaceutica Sinica B, Vol. 7, No. 2, 01.03.2017, p. 241-248.

Research output: Contribution to journalArticle

Yu, AM, Ingelman-Sundberg, M, Cherrington, NJ, Aleksunes, LM, Zanger, UM, Xie, W, Jeong, H, Morgan, EM, Turnbaugh, PJ, Klaassen, CD, Bhatt, AP, Redinbo, MR, Hao, P, Waxman, DJ, Wang, L & Zhong, XB 2017, 'Regulation of drug metabolism and toxicity by multiple factors of genetics, epigenetics, lncRNAs, gut microbiota, and diseases: a meeting report of the 21st International Symposium on Microsomes and Drug Oxidations (MDO)', Acta Pharmaceutica Sinica B, vol. 7, no. 2, pp. 241-248. https://doi.org/10.1016/j.apsb.2016.12.006
Yu, Ai Ming ; Ingelman-Sundberg, Magnus ; Cherrington, Nathan J ; Aleksunes, Lauren M. ; Zanger, Ulrich M. ; Xie, Wen ; Jeong, Hyunyoung ; Morgan, Edward M. ; Turnbaugh, Peter J. ; Klaassen, Curtis D. ; Bhatt, Aadra P. ; Redinbo, Matthew R. ; Hao, Pengying ; Waxman, David J. ; Wang, Li ; Zhong, Xiao bo. / Regulation of drug metabolism and toxicity by multiple factors of genetics, epigenetics, lncRNAs, gut microbiota, and diseases : a meeting report of the 21st International Symposium on Microsomes and Drug Oxidations (MDO). In: Acta Pharmaceutica Sinica B. 2017 ; Vol. 7, No. 2. pp. 241-248.
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