Regulation of gene expression and mitochondrial dynamics by SMAD

Nirav Shah, Nam Y. Lee

Research output: Contribution to journalComment/debate

Abstract

Mothers against decapentaplegic homolog (SMAD) proteins exert a wide spectrum of transcriptional effects in different cell types and tissues in response to transforming growth factor-β (TGF-β). A recent study demonstrates what is thought to be the first distinct cytoplasmic function for SMAD2 in modulating mitochondrial dynamics and hence reveals new pathophysiological implications for TGF-β signaling.

Original languageEnglish (US)
Article numbere1204492
JournalMolecular and Cellular Oncology
Volume3
Issue number5
DOIs
StatePublished - Sep 2 2016
Externally publishedYes

Keywords

  • MFN2
  • mitochondria
  • RIN1
  • SMAD
  • transforming growth factor beta

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine

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