Regulation of IgE synthesis in humans

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

At the present time, in no other system are the signals required for isotype switching better understood than in the IgE system. IgE switching is therefore becoming a general model for 'directed' isotype switching in mice and humans. The study of IgE regulation has proposed a paradigm of general importance for immunology in the nineties, namely, the requirement for at least two signals in order to trigger the final event, in this case DNA switch recombination to the IgE isotype. The first signal is delivered by a cytokine, IL-4 or IL-13, and is responsible for the choice of the isotype. The second signal is typically delivered upon engagement of CD40 on B cells by the CD40 ligand expressed on T cells, and results in switching and production of IgE. We shall herein discuss the two-signal model for IgE switching in detail, stressing in particular the cross-talk between signals, and the mechanisms responsible for IgE amplification.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalJournal of Biological Regulators and Homeostatic Agents
Volume9
Issue number1
StatePublished - 1995
Externally publishedYes

Fingerprint

Immunoglobulin E
synthesis
interleukin-4
immunology
B-lymphocytes
cytokines
Immunoglobulin Class Switching
T-lymphocytes
mice
DNA
CD40 Ligand
Interleukin-13
Allergy and Immunology
Interleukin-4
Genetic Recombination
B-Lymphocytes
Cytokines
T-Lymphocytes
interleukin-13
ligands

Keywords

  • CD40
  • CD40 ligand
  • Cytokines
  • IgE
  • IL-4
  • Switching

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Endocrinology
  • Physiology
  • Immunology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Physiology (medical)

Cite this

Regulation of IgE synthesis in humans. / Vercelli, Donata.

In: Journal of Biological Regulators and Homeostatic Agents, Vol. 9, No. 1, 1995, p. 1-6.

Research output: Contribution to journalArticle

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