Regulation of skeletal muscle satellite cell proliferation by bovine pituitary fibroblast growth factor

Ronald E Allen, Michael V. Dodson, Lynda S. Luiten

Research output: Contribution to journalArticle

117 Citations (Scopus)

Abstract

Satellite cells in skeletal muscle have been implicated in muscle growth processes and regeneration. However, very little is known about the regulation of their proliferation and differentiation. The effect of fibroblast growth factor (FGF) on the proliferation of myogenic cells from adult rat skeletal muscle, presumably satellite cells, has been examined, and FGF has been found to be a potent mitogen for these cells. The mitogenic properties of serum were also documented and studied in conjunction with FGF. Even under conditions of maximal stimulation by serum, the addition of FGF caused a substantial increase in proliferation of satellite cells. The additive nature of the FGF and serum-stimulatory activity suggests that FGF-like molecules are not the active agents in serum and that more than one pathway may be involved in stimulating satellite cell proliferation.

Original languageEnglish (US)
Pages (from-to)154-160
Number of pages7
JournalExperimental Cell Research
Volume152
Issue number1
DOIs
StatePublished - 1984

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Skeletal Muscle Satellite Cells
Fibroblast Growth Factors
Cell Proliferation
Serum
Mitogens
Regeneration
Muscles
Growth

ASJC Scopus subject areas

  • Cell Biology

Cite this

Regulation of skeletal muscle satellite cell proliferation by bovine pituitary fibroblast growth factor. / Allen, Ronald E; Dodson, Michael V.; Luiten, Lynda S.

In: Experimental Cell Research, Vol. 152, No. 1, 1984, p. 154-160.

Research output: Contribution to journalArticle

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