Related F-box proteins control cell death in caenorhabditis elegans and human lymphoma

Michael Chiorazzi, Lixin Rui, Yandan Yang, Michele Ceribelli, Nima Tishbi, Carine W. Maurer, Stella M. Ranuncolo, Hong Zhao, Weihong Xu, Wing Chung C Chan, Elaine S. Jaffe, Randy D. Gascoyne, Elias Campo, Andreas Rosenwald, German Ott, Jan Delabie, Lisa M Rimsza, Shai Shaham, Louis M. Staudt

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Cell death is a common metazoan cell fate, and its inactivation is central to human malignancy. In Caenorhabditis elegans, apoptotic cell death occurs via the activation of the caspase CED-3 following binding of the EGL-1/BH3-only protein to the antiapoptotic CED-9/ BCL2 protein. Here we report a major alternative mechanism for caspase activation in vivo involving the F-box protein DRE-1. DRE-1 functions in parallel to EGL-1, requires CED-9 for activity, and binds to CED-9, suggesting that DRE-1 promotes apoptosis by inactivating CED-9. FBXO10, a human protein related to DRE-1, binds BCL2 and promotes its degradation, thereby initiating cell death. Moreover, some human diffuse large B-cell lymphomas have inactivating mutations in FBXO10 or express FBXO10 at low levels. Our results suggest that DRE-1/FBXO10 is a conserved regulator of apoptosis.

Original languageEnglish (US)
Pages (from-to)3943-3948
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume110
Issue number10
DOIs
StatePublished - Mar 5 2013

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F-Box Proteins
Caenorhabditis elegans
Lymphoma
Cell Death
Proto-Oncogene Proteins c-bcl-2
Apoptosis
Lymphoma, Large B-Cell, Diffuse
Caspases
Caspase 3
Mutation
Neoplasms
Proteins

Keywords

  • Cancer
  • Ubiquitin

ASJC Scopus subject areas

  • General

Cite this

Related F-box proteins control cell death in caenorhabditis elegans and human lymphoma. / Chiorazzi, Michael; Rui, Lixin; Yang, Yandan; Ceribelli, Michele; Tishbi, Nima; Maurer, Carine W.; Ranuncolo, Stella M.; Zhao, Hong; Xu, Weihong; Chan, Wing Chung C; Jaffe, Elaine S.; Gascoyne, Randy D.; Campo, Elias; Rosenwald, Andreas; Ott, German; Delabie, Jan; Rimsza, Lisa M; Shaham, Shai; Staudt, Louis M.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, No. 10, 05.03.2013, p. 3943-3948.

Research output: Contribution to journalArticle

Chiorazzi, M, Rui, L, Yang, Y, Ceribelli, M, Tishbi, N, Maurer, CW, Ranuncolo, SM, Zhao, H, Xu, W, Chan, WCC, Jaffe, ES, Gascoyne, RD, Campo, E, Rosenwald, A, Ott, G, Delabie, J, Rimsza, LM, Shaham, S & Staudt, LM 2013, 'Related F-box proteins control cell death in caenorhabditis elegans and human lymphoma', Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 10, pp. 3943-3948. https://doi.org/10.1073/pnas.1217271110
Chiorazzi, Michael ; Rui, Lixin ; Yang, Yandan ; Ceribelli, Michele ; Tishbi, Nima ; Maurer, Carine W. ; Ranuncolo, Stella M. ; Zhao, Hong ; Xu, Weihong ; Chan, Wing Chung C ; Jaffe, Elaine S. ; Gascoyne, Randy D. ; Campo, Elias ; Rosenwald, Andreas ; Ott, German ; Delabie, Jan ; Rimsza, Lisa M ; Shaham, Shai ; Staudt, Louis M. / Related F-box proteins control cell death in caenorhabditis elegans and human lymphoma. In: Proceedings of the National Academy of Sciences of the United States of America. 2013 ; Vol. 110, No. 10. pp. 3943-3948.
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