Relation of physical activity time to incident disability in community dwelling adults with or at risk of knee arthritis

Prospective cohort study OPEN ACCESS

Dorothy D. Dunlop, Jing Song, Pamela A. Semanik, Leena Sharma, Joan M. Bathon, Charles B Eaton, Marc C. Hochberg, Rebecca D. Jackson, Chian K Kwoh, W. Jerry Mysiw, Michael C. Nevitt, Rowland W. Chang

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Objective To investigate whether objectively measured time spent in light intensity physical activity is related to incident disability and to disability progression. Design Prospective multisite cohort study from September 2008 to December 2012. Setting Baltimore, Maryland; Columbus, Ohio; Pittsburgh, Pennsylvania; and Pawtucket, Rhode Island, USA. Participants Disability onset cohort of 1680 community dwelling adults aged 49 years or older with knee osteoarthritis or risk factors for knee osteoarthritis; the disability progression cohort included 1814 adults. Main outcome measures Physical activity was measured by accelerometer monitoring. Disability was ascertained from limitations in instrumental and basic activities of daily living at baseline and two years. The primary outcome was incident disability. The secondary outcome was progression of disability defined by a more severe level (no limitations, limitations to instrumental activities only, 1-2 basic activities, or ≥3 basic activities) at two years compared with baseline. Results Greater time spent in light intensity activities had a significant inverse association with incident disability. Less incident disability and less disability progression were each significantly related to increasing quartile categories of daily time spent in light intensity physical activities (hazard ratios for disability onset 1.00, 0.62, 0.47, and 0.58, P for trend=0.007; hazard ratios for progression 1.00, 0.59, 0.50, and 0.53, P for trend=0.003) with control for socioeconomic factors (age, sex, race/ethnicity, education, income) and health factors (comorbidities, depressive symptoms, obesity, smoking, lower extremity pain and function, and knee assessments: osteoarthritis severity, pain, symptoms, prior injury). This finding was independent of time spent in moderate-vigorous activities. Conclusion These prospective data showed an association between greater daily time spent in light intensity physical activities and reduced risk of onset and progression of disability in adults with osteoarthritis of the knee or risk factors for knee osteoarthritis. An increase in daily physical activity time may reduce the risk of disability, even if the intensity of that additional activity is not increased.

Original languageEnglish (US)
Article numberg2472
JournalBMJ (Clinical research ed.)
Volume348
DOIs
StatePublished - Apr 29 2014

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Independent Living
Knee Osteoarthritis
Arthritis
Knee
Cohort Studies
Prospective Studies
Exercise
Light
Pain
Baltimore
Activities of Daily Living
Health Education
Comorbidity
Lower Extremity
Obesity
Smoking
Outcome Assessment (Health Care)
Depression
Wounds and Injuries

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Relation of physical activity time to incident disability in community dwelling adults with or at risk of knee arthritis : Prospective cohort study OPEN ACCESS. / Dunlop, Dorothy D.; Song, Jing; Semanik, Pamela A.; Sharma, Leena; Bathon, Joan M.; B Eaton, Charles; Hochberg, Marc C.; Jackson, Rebecca D.; Kwoh, Chian K; Mysiw, W. Jerry; Nevitt, Michael C.; Chang, Rowland W.

In: BMJ (Clinical research ed.), Vol. 348, g2472, 29.04.2014.

Research output: Contribution to journalArticle

Dunlop, DD, Song, J, Semanik, PA, Sharma, L, Bathon, JM, B Eaton, C, Hochberg, MC, Jackson, RD, Kwoh, CK, Mysiw, WJ, Nevitt, MC & Chang, RW 2014, 'Relation of physical activity time to incident disability in community dwelling adults with or at risk of knee arthritis: Prospective cohort study OPEN ACCESS', BMJ (Clinical research ed.), vol. 348, g2472. https://doi.org/10.1136/bmj.g2472
Dunlop, Dorothy D. ; Song, Jing ; Semanik, Pamela A. ; Sharma, Leena ; Bathon, Joan M. ; B Eaton, Charles ; Hochberg, Marc C. ; Jackson, Rebecca D. ; Kwoh, Chian K ; Mysiw, W. Jerry ; Nevitt, Michael C. ; Chang, Rowland W. / Relation of physical activity time to incident disability in community dwelling adults with or at risk of knee arthritis : Prospective cohort study OPEN ACCESS. In: BMJ (Clinical research ed.). 2014 ; Vol. 348.
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abstract = "Objective To investigate whether objectively measured time spent in light intensity physical activity is related to incident disability and to disability progression. Design Prospective multisite cohort study from September 2008 to December 2012. Setting Baltimore, Maryland; Columbus, Ohio; Pittsburgh, Pennsylvania; and Pawtucket, Rhode Island, USA. Participants Disability onset cohort of 1680 community dwelling adults aged 49 years or older with knee osteoarthritis or risk factors for knee osteoarthritis; the disability progression cohort included 1814 adults. Main outcome measures Physical activity was measured by accelerometer monitoring. Disability was ascertained from limitations in instrumental and basic activities of daily living at baseline and two years. The primary outcome was incident disability. The secondary outcome was progression of disability defined by a more severe level (no limitations, limitations to instrumental activities only, 1-2 basic activities, or ≥3 basic activities) at two years compared with baseline. Results Greater time spent in light intensity activities had a significant inverse association with incident disability. Less incident disability and less disability progression were each significantly related to increasing quartile categories of daily time spent in light intensity physical activities (hazard ratios for disability onset 1.00, 0.62, 0.47, and 0.58, P for trend=0.007; hazard ratios for progression 1.00, 0.59, 0.50, and 0.53, P for trend=0.003) with control for socioeconomic factors (age, sex, race/ethnicity, education, income) and health factors (comorbidities, depressive symptoms, obesity, smoking, lower extremity pain and function, and knee assessments: osteoarthritis severity, pain, symptoms, prior injury). This finding was independent of time spent in moderate-vigorous activities. Conclusion These prospective data showed an association between greater daily time spent in light intensity physical activities and reduced risk of onset and progression of disability in adults with osteoarthritis of the knee or risk factors for knee osteoarthritis. An increase in daily physical activity time may reduce the risk of disability, even if the intensity of that additional activity is not increased.",
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AU - Sharma, Leena

AU - Bathon, Joan M.

AU - B Eaton, Charles

AU - Hochberg, Marc C.

AU - Jackson, Rebecca D.

AU - Kwoh, Chian K

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