TY - JOUR
T1 - Relationship between fat distribution and cardiometabolic risk in Hispanic girls
AU - Hetherington-Rauth, Megan
AU - Bea, Jennifer W.
AU - Lee, Vinson R.
AU - Blew, Robert M.
AU - Funk, Janet L.
AU - Lohman, Timothy G.
AU - Going, Scott B.
N1 - Funding Information:
information Eunice Kennedy Shriver National Institute of Child Health and Human Development, Grant/Award Number: HD074565 The authors would like to thank the University of Arizona Collaboratory for Metabolic Disease Prevention and Treatment Center, where this investigation was completed. The study was funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (HD074565). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Child Health and Human Development or the National Institutes of Health. The authors have no conflicts of interest relevant to this article. The funder had no role in study design data collection, analysis, decision to publish, or preparation of the article. All authors gave critical feedback and approval prior to submission of the final article. Data collection: Megan Hetherington-Rauth, Vinson R. Lee, Robert M. Blew, and Jennifer W. Bea Data analysis: Megan Hetherington-Rauth and Timothy G. Lohman Data interpretation: Megan Hetherington-Rauth, Timothy G. Lohman, and Scott B. Going Article drafting: Megan Hetherington-Rauth
Funding Information:
The authors would like to thank the University of Arizona Collaboratory for Metabolic Disease Prevention and Treatment Center, where this investigation was completed. The study was funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (HD074565). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Child Health and Human Development or the National Institutes of Health. The authors have no conflicts of interest relevant to this article.
Publisher Copyright:
© 2018 Wiley Periodicals, Inc.
PY - 2018/9/1
Y1 - 2018/9/1
N2 - Objective: In adults, certain body fat depots have greater impact on cardiometabolic risk than total adiposity. Whether similar relationships exist in children is uncertain. The aim of this study was to examine the relationships among dual x-ray absorptiometry (DXA) measures of body fat distribution and total body adiposity with cardiometabolic risk factors in Hispanic girls. Methods: Measures of total percent body fat, percent of total fat within the android, gynoid, leg, and trunk regions, and cardiometabolic biomarkers (insulin, glucose, homeostatic model assessment of insulin resistance (HOMA-IR), triglycerides (TG), low and high lipoprotein cholesterol (LDL-C, HDL-C)) were obtained from 232 Hispanic girls (age 10.7 ±1.1 years). Regression models for each metabolic parameter were run against adiposity measures. Partial correlations of the adiposity measures were used to compare associations between adiposity measures and the cardiometabolic risk factors, controlling for somatic maturation. Results: Total and regional adiposity were significantly related with cardiometabolic risk factors (P < 0.05) except fasting glucose. The partial correlations of total and regional adiposity measures with each cardiometabolic biomarker were similar. More variance was explained for insulin and the HOMA-IR (33%-43%) than other risk factors. Partial correlations for the percentage of total fat in the gynoid and leg regions with insulin, HOMA-IR, TG, and LDL-C were negative, and positive with HDL-C. Conclusion: Measures of total and regional fat perform similarly in predicting cardiometabolic risk in Hispanic girls. A higher proportion of fat distributed in the gynoid or leg region is associated with lower cardiometabolic risk.
AB - Objective: In adults, certain body fat depots have greater impact on cardiometabolic risk than total adiposity. Whether similar relationships exist in children is uncertain. The aim of this study was to examine the relationships among dual x-ray absorptiometry (DXA) measures of body fat distribution and total body adiposity with cardiometabolic risk factors in Hispanic girls. Methods: Measures of total percent body fat, percent of total fat within the android, gynoid, leg, and trunk regions, and cardiometabolic biomarkers (insulin, glucose, homeostatic model assessment of insulin resistance (HOMA-IR), triglycerides (TG), low and high lipoprotein cholesterol (LDL-C, HDL-C)) were obtained from 232 Hispanic girls (age 10.7 ±1.1 years). Regression models for each metabolic parameter were run against adiposity measures. Partial correlations of the adiposity measures were used to compare associations between adiposity measures and the cardiometabolic risk factors, controlling for somatic maturation. Results: Total and regional adiposity were significantly related with cardiometabolic risk factors (P < 0.05) except fasting glucose. The partial correlations of total and regional adiposity measures with each cardiometabolic biomarker were similar. More variance was explained for insulin and the HOMA-IR (33%-43%) than other risk factors. Partial correlations for the percentage of total fat in the gynoid and leg regions with insulin, HOMA-IR, TG, and LDL-C were negative, and positive with HDL-C. Conclusion: Measures of total and regional fat perform similarly in predicting cardiometabolic risk in Hispanic girls. A higher proportion of fat distributed in the gynoid or leg region is associated with lower cardiometabolic risk.
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U2 - 10.1002/ajhb.23149
DO - 10.1002/ajhb.23149
M3 - Article
C2 - 30129276
AN - SCOPUS:85052663592
VL - 30
JO - American Journal of Human Biology
JF - American Journal of Human Biology
SN - 1042-0533
IS - 5
M1 - e23149
ER -