Relationship between infant weight gain and later asthma

Ian M. Paul, Lindsay Camera, Robert S. Zeiger, Theresa W. Guilbert, Leonard B. Bacharier, Lynn M. Taussig, Wayne J Morgan, Ronina A. Covar, Marzena Krawiec, Gordon R. Bloomberg, David T. Mauger

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Like obesity, the prevalence of asthma has increased over the past several decades. Accelerated patterns of infant growth have been associated with obesity and its co-morbidities. We aimed to determine if infant weight gain pattern is associated with asthma development later in childhood. Birth weight, growth, pulmonary function, and symptom data were collected in a trial of 2- to 3-yr-old children at-risk for asthma randomized to a 2-yr treatment with inhaled corticosteroids or placebo followed by a 1-yr observation period of study medication. Patterns of infant weight gain between birth and study enrollment were categorized as accelerated, average, or decelerated. Regression analyses were used to test the effects of infant weight gain pattern prior to study enrollment on outcomes during the observation year and at study conclusion while adjusting for demographics, baseline symptom severity, study treatment, and atopic indicators. Among the 197 study participants, early life weight gain pattern was not associated with daily asthma symptoms or lung function at the study's conclusion. However, both prednisone courses (p = 0.01) and urgent physician visits (p < 0.001) were significantly associated with weight gain pattern with fewer exacerbations occurring amongst those with a decelerated weight gain pattern. We conclude that early life patterns of weight change were associated with subsequent asthma exacerbations, but were not associated with asthma symptoms or pulmonary function during the pre-school years for these children at-risk for asthma.

Original languageEnglish (US)
Pages (from-to)82-89
Number of pages8
JournalPediatric Allergy and Immunology
Volume21
Issue number1 PART I
DOIs
StatePublished - Feb 2010

Fingerprint

Weight Gain
Asthma
Lung
Obesity
Observation
Growth
Prednisone
Birth Weight
Adrenal Cortex Hormones
Placebos
Regression Analysis
Demography
Parturition
Morbidity
Physicians
Weights and Measures
Therapeutics

Keywords

  • Asthma
  • Infant
  • Weight gain

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pediatrics, Perinatology, and Child Health
  • Immunology

Cite this

Paul, I. M., Camera, L., Zeiger, R. S., Guilbert, T. W., Bacharier, L. B., Taussig, L. M., ... Mauger, D. T. (2010). Relationship between infant weight gain and later asthma. Pediatric Allergy and Immunology, 21(1 PART I), 82-89. https://doi.org/10.1111/j.1399-3038.2009.00926.x

Relationship between infant weight gain and later asthma. / Paul, Ian M.; Camera, Lindsay; Zeiger, Robert S.; Guilbert, Theresa W.; Bacharier, Leonard B.; Taussig, Lynn M.; Morgan, Wayne J; Covar, Ronina A.; Krawiec, Marzena; Bloomberg, Gordon R.; Mauger, David T.

In: Pediatric Allergy and Immunology, Vol. 21, No. 1 PART I, 02.2010, p. 82-89.

Research output: Contribution to journalArticle

Paul, IM, Camera, L, Zeiger, RS, Guilbert, TW, Bacharier, LB, Taussig, LM, Morgan, WJ, Covar, RA, Krawiec, M, Bloomberg, GR & Mauger, DT 2010, 'Relationship between infant weight gain and later asthma', Pediatric Allergy and Immunology, vol. 21, no. 1 PART I, pp. 82-89. https://doi.org/10.1111/j.1399-3038.2009.00926.x
Paul IM, Camera L, Zeiger RS, Guilbert TW, Bacharier LB, Taussig LM et al. Relationship between infant weight gain and later asthma. Pediatric Allergy and Immunology. 2010 Feb;21(1 PART I):82-89. https://doi.org/10.1111/j.1399-3038.2009.00926.x
Paul, Ian M. ; Camera, Lindsay ; Zeiger, Robert S. ; Guilbert, Theresa W. ; Bacharier, Leonard B. ; Taussig, Lynn M. ; Morgan, Wayne J ; Covar, Ronina A. ; Krawiec, Marzena ; Bloomberg, Gordon R. ; Mauger, David T. / Relationship between infant weight gain and later asthma. In: Pediatric Allergy and Immunology. 2010 ; Vol. 21, No. 1 PART I. pp. 82-89.
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