Relationship between lifetime occupation and parietal flow: Implications for a reserve against Alzheimer's disease pathology

Y. Stern, Gene E Alexander, I. Prohovnik, L. Stricks, B. Link, M. C. Lennon, R. Mayeux

Research output: Contribution to journalArticle

208 Citations (Scopus)

Abstract

We previously reported an inverse relation between parietal cerebral blood flow and years of education in Alzheimer's disease (AD) patients matched for clinical severity. This suggested that the clinical manifestation of advancing AD pathology is delayed in patients with higher educational attainment. Other aspects of life experience may also provide a reserve against the clinical expression of AD. To test this hypothesis, we classified the primary lifetime occupations of 51 AD patients using the Dictionary of Occupational Titles, published by the US Department of Labor, and derived six factor scores describing intellectual, interpersonal, and physical job demands. Regional cerebral blood flow was measured using the xenon-133 inhalation method. After controlling for age, clinical dementia severity, and education, there was less relative perfusion in the parietal region in subjects whose occupations were associated with higher interpersonal skills and physical demands factor scores. We conclude that independent of education, aspects of occupational experience may provide a reserve that delays the clinical manifestation of AD.

Original languageEnglish (US)
Pages (from-to)55-60
Number of pages6
JournalNeurology
Volume45
Issue number1
StatePublished - Jan 1995
Externally publishedYes

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Occupations
Alzheimer Disease
Pathology
Cerebrovascular Circulation
Education
Parietal Lobe
Xenon
Life Change Events
Regional Blood Flow
Inhalation
Dementia
Perfusion

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Stern, Y., Alexander, G. E., Prohovnik, I., Stricks, L., Link, B., Lennon, M. C., & Mayeux, R. (1995). Relationship between lifetime occupation and parietal flow: Implications for a reserve against Alzheimer's disease pathology. Neurology, 45(1), 55-60.

Relationship between lifetime occupation and parietal flow : Implications for a reserve against Alzheimer's disease pathology. / Stern, Y.; Alexander, Gene E; Prohovnik, I.; Stricks, L.; Link, B.; Lennon, M. C.; Mayeux, R.

In: Neurology, Vol. 45, No. 1, 01.1995, p. 55-60.

Research output: Contribution to journalArticle

Stern, Y, Alexander, GE, Prohovnik, I, Stricks, L, Link, B, Lennon, MC & Mayeux, R 1995, 'Relationship between lifetime occupation and parietal flow: Implications for a reserve against Alzheimer's disease pathology', Neurology, vol. 45, no. 1, pp. 55-60.
Stern, Y. ; Alexander, Gene E ; Prohovnik, I. ; Stricks, L. ; Link, B. ; Lennon, M. C. ; Mayeux, R. / Relationship between lifetime occupation and parietal flow : Implications for a reserve against Alzheimer's disease pathology. In: Neurology. 1995 ; Vol. 45, No. 1. pp. 55-60.
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