Relationship between Polysorbate 80 solubilization descriptors and octanol-water partition coefficients of drugs

F. A. Alvarez-Núñez, S. H. Yalkowsky

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

The molar solubilization capacities (κ) and the molar micelle-water partition coefficients (K(M)(N)) in Polysorbate 80 of several drugs (including barbiturates, steroids, and benzoic acid derivatives) are related to their log octanol-water partition coefficients (logP). Both κ and K(M)(N) values were calculated from solubility versus Polysorbate 80 concentration profiles, which were either experimentally determined or obtained from the literature. There is a linear relationship between logP of the tested compounds and the logarithm of the molar micelle-water partition coefficient (logK(M)(N)). On the other hand molar solubilization capacities are nearly independent of logP. It is shown that the ability of Polysorbate 80 to solubilize a drug can be predicted from its logP value. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)217-222
Number of pages6
JournalInternational Journal of Pharmaceutics
Volume200
Issue number2
DOIs
StatePublished - May 10 2000

Keywords

  • Octanol-water
  • Partition coefficients
  • Polysorbate 80
  • Solubilization descriptors

ASJC Scopus subject areas

  • Pharmaceutical Science

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