Relationship between the expression of surface markers and synthesis of immunoglobulin E by peripheral blood mononuclear cells under the influence of recombinant interleukin-4

R. G. Vasilov, L. K. Chelidze, Yu S. Lebedin, S. V. Chukanova, E. N. Tsytsikov, V. I. Pivnyuk

Research output: Contribution to journalArticle

Abstract

The relationship between interleukin-4-induced synthesis of immunoglobulin E (IgE) by peripheral blood mononuclear cells of healthy donors and the expression of T- and B-cell surface differentiating markers is studied. It is demonstrated that the high level of IgE response on day 10 of culturing correlates with a higher level of expression of the T-cell activation markers HLA-DR and CD25 and a low level of expression of the low-affinity IgE receptor CD23 on the surface of B cells. Activation of T cells is interleukin-4-independent, since it occurs to an equal degree when these cells are cultured without interleukin-4.

Original languageEnglish (US)
Pages (from-to)1121-1125
Number of pages5
JournalBulletin of Experimental Biology and Medicine
Volume118
Issue number4
DOIs
StatePublished - Oct 1 1994
Externally publishedYes

Keywords

  • immunoglobulin E
  • interleukin-4
  • surface antigens

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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