Relative bioavailability of commercial ampicillin formulations in man

Michael Mayersohn, L. Endrenyi

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The relative bioavailability of three commercial ampicillin products was examined in 12 human subjects using a crossover experimental design. Based upon the areas under the ampicillin plasma concentration time curves after the oral administration of 250 mg. ampicillin and using an analysis of variance technique, no statistically significant differences were found between the products examined. These findings are in contrast to those of a recent report and appear to be explained by formulation differences. These relatively minor differences in formulation reflect the importance of formulation variables in providing efficient drug therapy. The intrasubject variation associated with several of these products is quite marked and is consistent with the incomplete and erratic absorption of this antibiotic in man.

Original languageEnglish (US)
Pages (from-to)989-993
Number of pages5
JournalCanadian Medical Association Journal
Volume109
Issue number10
StatePublished - 1973
Externally publishedYes

Fingerprint

Ampicillin
Biological Availability
Cross-Over Studies
Oral Administration
Analysis of Variance
Research Design
Anti-Bacterial Agents
Drug Therapy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Relative bioavailability of commercial ampicillin formulations in man. / Mayersohn, Michael; Endrenyi, L.

In: Canadian Medical Association Journal, Vol. 109, No. 10, 1973, p. 989-993.

Research output: Contribution to journalArticle

@article{3cc5b178cd1b436986cb922ab5cad533,
title = "Relative bioavailability of commercial ampicillin formulations in man",
abstract = "The relative bioavailability of three commercial ampicillin products was examined in 12 human subjects using a crossover experimental design. Based upon the areas under the ampicillin plasma concentration time curves after the oral administration of 250 mg. ampicillin and using an analysis of variance technique, no statistically significant differences were found between the products examined. These findings are in contrast to those of a recent report and appear to be explained by formulation differences. These relatively minor differences in formulation reflect the importance of formulation variables in providing efficient drug therapy. The intrasubject variation associated with several of these products is quite marked and is consistent with the incomplete and erratic absorption of this antibiotic in man.",
author = "Michael Mayersohn and L. Endrenyi",
year = "1973",
language = "English (US)",
volume = "109",
pages = "989--993",
journal = "CMAJ",
issn = "0820-3946",
publisher = "Canadian Medical Association",
number = "10",

}

TY - JOUR

T1 - Relative bioavailability of commercial ampicillin formulations in man

AU - Mayersohn, Michael

AU - Endrenyi, L.

PY - 1973

Y1 - 1973

N2 - The relative bioavailability of three commercial ampicillin products was examined in 12 human subjects using a crossover experimental design. Based upon the areas under the ampicillin plasma concentration time curves after the oral administration of 250 mg. ampicillin and using an analysis of variance technique, no statistically significant differences were found between the products examined. These findings are in contrast to those of a recent report and appear to be explained by formulation differences. These relatively minor differences in formulation reflect the importance of formulation variables in providing efficient drug therapy. The intrasubject variation associated with several of these products is quite marked and is consistent with the incomplete and erratic absorption of this antibiotic in man.

AB - The relative bioavailability of three commercial ampicillin products was examined in 12 human subjects using a crossover experimental design. Based upon the areas under the ampicillin plasma concentration time curves after the oral administration of 250 mg. ampicillin and using an analysis of variance technique, no statistically significant differences were found between the products examined. These findings are in contrast to those of a recent report and appear to be explained by formulation differences. These relatively minor differences in formulation reflect the importance of formulation variables in providing efficient drug therapy. The intrasubject variation associated with several of these products is quite marked and is consistent with the incomplete and erratic absorption of this antibiotic in man.

UR - http://www.scopus.com/inward/record.url?scp=0015718647&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015718647&partnerID=8YFLogxK

M3 - Article

VL - 109

SP - 989

EP - 993

JO - CMAJ

JF - CMAJ

SN - 0820-3946

IS - 10

ER -