Remarkable three-step-one-pot solution phase preparation of novel imidazolines utilizing a UDC (Ugi/de-Boc/cyclize) strategy

Christopher Hulme, Liang Ma, Joseph Romano, Matthew Morrissette

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

This communication reveals the novel solution phase synthesis of an array of biologically relevant imidazolines in a remarkable 'three-step-one-pot' procedure, utilizing a Ugi/de-Boc/cyclization (UDC) strategy. Transformations are carried out in excellent yield by condensation of N-Boc-α-amino-aldehydes and supporting Ugi reagents. The described protocol represents a highly attractive solution phase procedure for the rapid generation of this class of molecule.

Original languageEnglish (US)
Pages (from-to)7925-7928
Number of pages4
JournalTetrahedron Letters
Volume40
Issue number45
DOIs
StatePublished - Nov 5 1999
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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