Remodeling an infarcted heart: novel hybrid treatment with transmyocardial revascularization and stem cell therapy

Jessika Iwanski, Raymond K. Wong, Douglas F. Larson, Alice S. Ferng, Raymond B. Runyan, Steven Goldstein, Zain Khalpey

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Transmyocardial revascularization (TMR) has emerged as an additional therapeutic option for patients suffering from diffuse coronary artery disease (CAD), providing immediate angina relief. Recent studies indicate that the volume of surgical cases being performed with TMR have been steadily rising, utilizing TMR as an adjunctive therapy. Therefore the purpose of this review is to provide an up-to-date appreciation of the current state of TMR and its future developmental directions on CAD treatment. The current potential of this therapy focuses on the implementation of stem cells, in order to create a synergistic angiogenic effect while increasing myocardial repair and regeneration. Although TMR procedures provide increased vascularization within the myocardium, patients suffering from ischemic cardiomyopathy may not benefit from angiogenesis alone. Therefore, the goal of introducing stem cells is to restore the functional state of a failing heart by providing these cells with a favorable microenvironment that will enhance stem cell engraftment.

Original languageEnglish (US)
Article number738
JournalSpringerPlus
Volume5
Issue number1
DOIs
StatePublished - Dec 1 2016

Keywords

  • Angina
  • CABG
  • Coronary artery disease
  • Laser therapy
  • Myocardial infarction
  • Stem cell therapy
  • Transmyocardial revascularization

ASJC Scopus subject areas

  • General

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