Renal gene transfer: Nonviral approaches

Yeong Hau H. Lien, Li Wen Lai

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

Gene therapy has the potential to become an important modality for treating both hereditary and acquired renal diseases. Since renal diseases may involve different cell types in the kidney, it is critical to achieve efficient gene transfer specifically to each cell type. We reviewed the literature on nonviral gene transfer techniques, which are designed to target the kidney specifically. A variety of approaches have been developed to target glomeruli, tubules, renal vasculature, and interstitium with different degree of success. Besides using delivery systems based on liposomes, polycations, and viral fusion proteins, investigators have adopted newer approaches including electroporation and hydrodynamic-based gene transfer, and demonstrated that they are efficient and safe in animal models. Potential clinical applications and safety concerns of gene therapy for renal diseases are discussed.

Original languageEnglish (US)
Pages (from-to)283-294
Number of pages12
JournalApplied Biochemistry and Biotechnology - Part B Molecular Biotechnology
Volume24
Issue number3
DOIs
StatePublished - Jul 1 2003

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Keywords

  • Gene therapy
  • Gene transfer
  • Glomerulus
  • Kidney
  • Renal tubules

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology

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