Repeat protein architectures predicted by a continuum representation of fold space

Andrew C. Hausrath, Alain Goriely

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

It is an open question whether nature has utilized all possible protein folds. For a simple protein architecture, the helical repeats, we report a method to address this question based on a mapping between the set of repetitive curves and a space of parameters specifying the curve. The exploration of the parameter space for a particular architecture enables a systematic exploration of the fold space for that protein architecture. In a planar subspace of the parameter space of helical repeats we have identified points corresponding to both naturally occurring folds and potential folds not observed so far.

Original languageEnglish (US)
Pages (from-to)753-760
Number of pages8
JournalProtein Science
Volume15
Issue number4
DOIs
StatePublished - Apr 2006

Keywords

  • Fold evolution
  • Polyhelix
  • Protein fold space
  • Repeat proteins

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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