Replication of prostate cancer risk loci on 8q24, 11q13, 17q12, 19q33, and Xp11 in African Americans

Stanley Hooker, Wenndy Hernandez, Hankui Chen, Christiane Robbins, Jada Benn Torres, Chiledum Ahaghotu, John Carpten, Rick A Kittles

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

BACKGROUND. Prostate cancer (Pca) is a common malignancy that disproportionately affects African American men (AA). Recently there have been several genome-wide association studies (GWAS) implicating new prostate cancer risk loci along chromosomes 2, 3, 6, 7, 8, 10, 11, 12, 17, 19, and X in populations of European ancestry. Given the higher incidence and mortality for AAs, and differences in allele frequencies and haplotype structures between African and European descent populations, it is important to assess the impact of these candidate risk loci in AAs. METHODS. Here we evaluated 20 single nucleotide polymorphisms (SNPs) associated with prostate cancer risk in recent GWAS studies, in AA prostate cancer cases and controls. RESULTS. We replicated five of the SNPs in our AA population, rs10896449 on 11q13.2 (P=0.009), rs2735839 on 19q33.33 region, (P=0.04), rs443076 on chromosome 17q12 (P=0.008), rs5945572 on Xp11.22 (P=0.05), as well as the rare variant specific to west African ancestry, bd11934905 in region 2 of 8q24 (P=1×10-4). CONCLUSIONS. While we were able to replicate a few of the previous GWASSNPs, we were not able to confirm the vast majority of these associations in our AA population. This finding further supports the need to perform GWAS and additional fine mapping in AAs to locate additional susceptibility loci.

Original languageEnglish (US)
Pages (from-to)270-275
Number of pages6
JournalProstate
Volume70
Issue number3
DOIs
StatePublished - Feb 15 2010
Externally publishedYes

Fingerprint

African Americans
Genome-Wide Association Study
Prostatic Neoplasms
Population
Single Nucleotide Polymorphism
Chromosomes, Human, Pair 3
Chromosomes, Human, Pair 2
Gene Frequency
Haplotypes
Chromosomes
Mortality
Incidence
Neoplasms

Keywords

  • African-Americans
  • Genetic risk
  • GWAS
  • Prostate cancer
  • SNPs

ASJC Scopus subject areas

  • Urology
  • Oncology

Cite this

Replication of prostate cancer risk loci on 8q24, 11q13, 17q12, 19q33, and Xp11 in African Americans. / Hooker, Stanley; Hernandez, Wenndy; Chen, Hankui; Robbins, Christiane; Torres, Jada Benn; Ahaghotu, Chiledum; Carpten, John; Kittles, Rick A.

In: Prostate, Vol. 70, No. 3, 15.02.2010, p. 270-275.

Research output: Contribution to journalArticle

Hooker, S, Hernandez, W, Chen, H, Robbins, C, Torres, JB, Ahaghotu, C, Carpten, J & Kittles, RA 2010, 'Replication of prostate cancer risk loci on 8q24, 11q13, 17q12, 19q33, and Xp11 in African Americans', Prostate, vol. 70, no. 3, pp. 270-275. https://doi.org/10.1002/pros.21061
Hooker S, Hernandez W, Chen H, Robbins C, Torres JB, Ahaghotu C et al. Replication of prostate cancer risk loci on 8q24, 11q13, 17q12, 19q33, and Xp11 in African Americans. Prostate. 2010 Feb 15;70(3):270-275. https://doi.org/10.1002/pros.21061
Hooker, Stanley ; Hernandez, Wenndy ; Chen, Hankui ; Robbins, Christiane ; Torres, Jada Benn ; Ahaghotu, Chiledum ; Carpten, John ; Kittles, Rick A. / Replication of prostate cancer risk loci on 8q24, 11q13, 17q12, 19q33, and Xp11 in African Americans. In: Prostate. 2010 ; Vol. 70, No. 3. pp. 270-275.
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AU - Hooker, Stanley

AU - Hernandez, Wenndy

AU - Chen, Hankui

AU - Robbins, Christiane

AU - Torres, Jada Benn

AU - Ahaghotu, Chiledum

AU - Carpten, John

AU - Kittles, Rick A

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N2 - BACKGROUND. Prostate cancer (Pca) is a common malignancy that disproportionately affects African American men (AA). Recently there have been several genome-wide association studies (GWAS) implicating new prostate cancer risk loci along chromosomes 2, 3, 6, 7, 8, 10, 11, 12, 17, 19, and X in populations of European ancestry. Given the higher incidence and mortality for AAs, and differences in allele frequencies and haplotype structures between African and European descent populations, it is important to assess the impact of these candidate risk loci in AAs. METHODS. Here we evaluated 20 single nucleotide polymorphisms (SNPs) associated with prostate cancer risk in recent GWAS studies, in AA prostate cancer cases and controls. RESULTS. We replicated five of the SNPs in our AA population, rs10896449 on 11q13.2 (P=0.009), rs2735839 on 19q33.33 region, (P=0.04), rs443076 on chromosome 17q12 (P=0.008), rs5945572 on Xp11.22 (P=0.05), as well as the rare variant specific to west African ancestry, bd11934905 in region 2 of 8q24 (P=1×10-4). CONCLUSIONS. While we were able to replicate a few of the previous GWASSNPs, we were not able to confirm the vast majority of these associations in our AA population. This finding further supports the need to perform GWAS and additional fine mapping in AAs to locate additional susceptibility loci.

AB - BACKGROUND. Prostate cancer (Pca) is a common malignancy that disproportionately affects African American men (AA). Recently there have been several genome-wide association studies (GWAS) implicating new prostate cancer risk loci along chromosomes 2, 3, 6, 7, 8, 10, 11, 12, 17, 19, and X in populations of European ancestry. Given the higher incidence and mortality for AAs, and differences in allele frequencies and haplotype structures between African and European descent populations, it is important to assess the impact of these candidate risk loci in AAs. METHODS. Here we evaluated 20 single nucleotide polymorphisms (SNPs) associated with prostate cancer risk in recent GWAS studies, in AA prostate cancer cases and controls. RESULTS. We replicated five of the SNPs in our AA population, rs10896449 on 11q13.2 (P=0.009), rs2735839 on 19q33.33 region, (P=0.04), rs443076 on chromosome 17q12 (P=0.008), rs5945572 on Xp11.22 (P=0.05), as well as the rare variant specific to west African ancestry, bd11934905 in region 2 of 8q24 (P=1×10-4). CONCLUSIONS. While we were able to replicate a few of the previous GWASSNPs, we were not able to confirm the vast majority of these associations in our AA population. This finding further supports the need to perform GWAS and additional fine mapping in AAs to locate additional susceptibility loci.

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