Residential Proximity to Major Roadways Is Associated with Increased Levels of AC133+ Circulating Angiogenic Cells

Natasha DeJarnett, Ray Yeager, Daniel J. Conklin, Jongmin Lee, Timothy E. O'Toole, James McCracken, Wes Abplanalp, Sanjay Srivastava, Daniel W. Riggs, Ihab Hamzeh, Stephen Wagner, Atul Chugh, Andrew Defilippis, Tiffany Ciszewski, Brad Wyatt, Carrie Becher, Deirdre Higdon, Kenneth Ramos, David J. Tollerud, John A. Myers & 6 others Shesh N. Rai, Jasmit Shah, Nagma Zafar, Sathya S. Krishnasamy, Sumanth D. Prabhu, Aruni Bhatnagar

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Objectives-Previous studies have shown that residential proximity to a roadway is associated with increased cardiovascular disease risk. Yet, the nature of this association remains unclear, and its effect on individual cardiovascular disease risk factors has not been assessed. The objective of this study was to determine whether residential proximity to roadways influences systemic inflammation and the levels of circulating angiogenic cells. Approach and Results-In a cross-sectional study, cardiovascular disease risk factors, blood levels of C-reactive protein, and 15 antigenically defined circulating angiogenic cell populations were measured in participants (n=316) with moderate-to-high cardiovascular disease risk. Attributes of roadways surrounding residential locations were assessed using geographic information systems. Associations between road proximity and cardiovascular indices were analyzed using generalized linear models. Close proximity (+/AC133+, AC133+, CD34+/AC133+, and CD34+/45dim/AC133+ cells) and positively associated with road segment distance (CD31+/AC133+, AC133+, and CD34+/AC133+ cells), traffic intensity (CD31+/AC133+ and AC133+ cells), and distance-weighted traffic intensity (CD31+/34+/45+/AC133+ cells). Conclusions-Living close to a major roadway is associated with elevated levels of circulating cells positive for the early stem marker AC133+. This may reflect an increased need for vascular repair. Levels of these cells in peripheral blood may be a sensitive index of cardiovascular injury because of residential proximity to roadways.

Original languageEnglish (US)
Pages (from-to)2468-2477
Number of pages10
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume35
Issue number11
DOIs
StatePublished - Nov 1 2015
Externally publishedYes

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Cardiovascular Diseases
Geographic Information Systems
C-Reactive Protein
Blood Vessels
Linear Models
Cross-Sectional Studies
Inflammation
Wounds and Injuries
Population

Keywords

  • air pollution
  • cardiovascular diseases
  • endothelial progenitor cells
  • epidemiology
  • risk factors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Residential Proximity to Major Roadways Is Associated with Increased Levels of AC133+ Circulating Angiogenic Cells. / DeJarnett, Natasha; Yeager, Ray; Conklin, Daniel J.; Lee, Jongmin; O'Toole, Timothy E.; McCracken, James; Abplanalp, Wes; Srivastava, Sanjay; Riggs, Daniel W.; Hamzeh, Ihab; Wagner, Stephen; Chugh, Atul; Defilippis, Andrew; Ciszewski, Tiffany; Wyatt, Brad; Becher, Carrie; Higdon, Deirdre; Ramos, Kenneth; Tollerud, David J.; Myers, John A.; Rai, Shesh N.; Shah, Jasmit; Zafar, Nagma; Krishnasamy, Sathya S.; Prabhu, Sumanth D.; Bhatnagar, Aruni.

In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 35, No. 11, 01.11.2015, p. 2468-2477.

Research output: Contribution to journalArticle

DeJarnett, N, Yeager, R, Conklin, DJ, Lee, J, O'Toole, TE, McCracken, J, Abplanalp, W, Srivastava, S, Riggs, DW, Hamzeh, I, Wagner, S, Chugh, A, Defilippis, A, Ciszewski, T, Wyatt, B, Becher, C, Higdon, D, Ramos, K, Tollerud, DJ, Myers, JA, Rai, SN, Shah, J, Zafar, N, Krishnasamy, SS, Prabhu, SD & Bhatnagar, A 2015, 'Residential Proximity to Major Roadways Is Associated with Increased Levels of AC133+ Circulating Angiogenic Cells', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 35, no. 11, pp. 2468-2477. https://doi.org/10.1161/ATVBAHA.115.305724
DeJarnett, Natasha ; Yeager, Ray ; Conklin, Daniel J. ; Lee, Jongmin ; O'Toole, Timothy E. ; McCracken, James ; Abplanalp, Wes ; Srivastava, Sanjay ; Riggs, Daniel W. ; Hamzeh, Ihab ; Wagner, Stephen ; Chugh, Atul ; Defilippis, Andrew ; Ciszewski, Tiffany ; Wyatt, Brad ; Becher, Carrie ; Higdon, Deirdre ; Ramos, Kenneth ; Tollerud, David J. ; Myers, John A. ; Rai, Shesh N. ; Shah, Jasmit ; Zafar, Nagma ; Krishnasamy, Sathya S. ; Prabhu, Sumanth D. ; Bhatnagar, Aruni. / Residential Proximity to Major Roadways Is Associated with Increased Levels of AC133+ Circulating Angiogenic Cells. In: Arteriosclerosis, Thrombosis, and Vascular Biology. 2015 ; Vol. 35, No. 11. pp. 2468-2477.
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T1 - Residential Proximity to Major Roadways Is Associated with Increased Levels of AC133+ Circulating Angiogenic Cells

AU - DeJarnett, Natasha

AU - Yeager, Ray

AU - Conklin, Daniel J.

AU - Lee, Jongmin

AU - O'Toole, Timothy E.

AU - McCracken, James

AU - Abplanalp, Wes

AU - Srivastava, Sanjay

AU - Riggs, Daniel W.

AU - Hamzeh, Ihab

AU - Wagner, Stephen

AU - Chugh, Atul

AU - Defilippis, Andrew

AU - Ciszewski, Tiffany

AU - Wyatt, Brad

AU - Becher, Carrie

AU - Higdon, Deirdre

AU - Ramos, Kenneth

AU - Tollerud, David J.

AU - Myers, John A.

AU - Rai, Shesh N.

AU - Shah, Jasmit

AU - Zafar, Nagma

AU - Krishnasamy, Sathya S.

AU - Prabhu, Sumanth D.

AU - Bhatnagar, Aruni

PY - 2015/11/1

Y1 - 2015/11/1

N2 - Objectives-Previous studies have shown that residential proximity to a roadway is associated with increased cardiovascular disease risk. Yet, the nature of this association remains unclear, and its effect on individual cardiovascular disease risk factors has not been assessed. The objective of this study was to determine whether residential proximity to roadways influences systemic inflammation and the levels of circulating angiogenic cells. Approach and Results-In a cross-sectional study, cardiovascular disease risk factors, blood levels of C-reactive protein, and 15 antigenically defined circulating angiogenic cell populations were measured in participants (n=316) with moderate-to-high cardiovascular disease risk. Attributes of roadways surrounding residential locations were assessed using geographic information systems. Associations between road proximity and cardiovascular indices were analyzed using generalized linear models. Close proximity (+/AC133+, AC133+, CD34+/AC133+, and CD34+/45dim/AC133+ cells) and positively associated with road segment distance (CD31+/AC133+, AC133+, and CD34+/AC133+ cells), traffic intensity (CD31+/AC133+ and AC133+ cells), and distance-weighted traffic intensity (CD31+/34+/45+/AC133+ cells). Conclusions-Living close to a major roadway is associated with elevated levels of circulating cells positive for the early stem marker AC133+. This may reflect an increased need for vascular repair. Levels of these cells in peripheral blood may be a sensitive index of cardiovascular injury because of residential proximity to roadways.

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