Resistance to intestinal parasites during murine AIDS

Role of alcohol and nutrition in immune dysfunction

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

A murine AIDS model with many similarities to human AIDS, LP-BM5 Murine Leukaemia, suppresses T and B cell numbers and functions in the intestine. This permits chronic colonization by Giardia and Cryptosporidium. Cocaine and the nutrient alcohol, which are immunosuppressive, further reduce resistance to intestinal parasites and intestinal lymphocyte numbers. Protein undernutrition, vitamin E supplementation, and alcohol use further modify immune dysfunction induced by the murine retrovirus infection. This suggests that both undernutrition and nutrient supplementation could affect parasite resistance during AIDS. Thus this murine model of human AIDS has great potential to accelerate studies of the role of nutrients in immune dysfunction and resistance to intestinal parasites.

Original languageEnglish (US)
JournalParasitology
Volume107
Issue numberSUPPL.
StatePublished - 1993

Fingerprint

Murine Acquired Immunodeficiency Syndrome
Parasites
Acquired Immunodeficiency Syndrome
alcohols
Alcohols
nutrition
parasites
Food
Malnutrition
malnutrition
mice
nutrients
Retroviridae
Retroviridae Infections
Giardia
cocaine
immunosuppressive agents
Cryptosporidium
lymphocyte count
Lymphocyte Count

Keywords

  • Cryptosporidium
  • Giardia
  • retrovirus
  • T-lymphocytes

ASJC Scopus subject areas

  • Immunology
  • Parasitology

Cite this

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title = "Resistance to intestinal parasites during murine AIDS: Role of alcohol and nutrition in immune dysfunction",
abstract = "A murine AIDS model with many similarities to human AIDS, LP-BM5 Murine Leukaemia, suppresses T and B cell numbers and functions in the intestine. This permits chronic colonization by Giardia and Cryptosporidium. Cocaine and the nutrient alcohol, which are immunosuppressive, further reduce resistance to intestinal parasites and intestinal lymphocyte numbers. Protein undernutrition, vitamin E supplementation, and alcohol use further modify immune dysfunction induced by the murine retrovirus infection. This suggests that both undernutrition and nutrient supplementation could affect parasite resistance during AIDS. Thus this murine model of human AIDS has great potential to accelerate studies of the role of nutrients in immune dysfunction and resistance to intestinal parasites.",
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T2 - Role of alcohol and nutrition in immune dysfunction

AU - Watson, Ronald R

PY - 1993

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N2 - A murine AIDS model with many similarities to human AIDS, LP-BM5 Murine Leukaemia, suppresses T and B cell numbers and functions in the intestine. This permits chronic colonization by Giardia and Cryptosporidium. Cocaine and the nutrient alcohol, which are immunosuppressive, further reduce resistance to intestinal parasites and intestinal lymphocyte numbers. Protein undernutrition, vitamin E supplementation, and alcohol use further modify immune dysfunction induced by the murine retrovirus infection. This suggests that both undernutrition and nutrient supplementation could affect parasite resistance during AIDS. Thus this murine model of human AIDS has great potential to accelerate studies of the role of nutrients in immune dysfunction and resistance to intestinal parasites.

AB - A murine AIDS model with many similarities to human AIDS, LP-BM5 Murine Leukaemia, suppresses T and B cell numbers and functions in the intestine. This permits chronic colonization by Giardia and Cryptosporidium. Cocaine and the nutrient alcohol, which are immunosuppressive, further reduce resistance to intestinal parasites and intestinal lymphocyte numbers. Protein undernutrition, vitamin E supplementation, and alcohol use further modify immune dysfunction induced by the murine retrovirus infection. This suggests that both undernutrition and nutrient supplementation could affect parasite resistance during AIDS. Thus this murine model of human AIDS has great potential to accelerate studies of the role of nutrients in immune dysfunction and resistance to intestinal parasites.

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KW - Giardia

KW - retrovirus

KW - T-lymphocytes

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