Response of human epileptic temporal lobe cortical blood flow to hyperventilation

Martin E Weinand, L. Philip Carter, Kalarickal J. Oommen, Ron Hutzler, David M Labiner, Dinesh Talwar, Waleed El-Saadany, Geoffrey L Ahern

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Bilateral long-term surface cortical cerebral blood flow (CBF) and electrocorticographic (ECoG) monitoring were performed in eight patients with complex partial seizures. In each patient, the epileptic temporal lobe was localized using ictal ECoG. Mean seizure interval (frequency-1) off anticonvulsant medication, a clinical measure of epileptogenicity, was 1.0 ± 0.3 h (range: 0.4 to 2.5 h). During 13 interictal hyperventilation periods, 3.6 ± 0.6 min in duration, the mean decrease in epileptic and nonepileptic temporal cortical CBF was 13.7 ± 2.3 versus 6.4 ± 1.9 ml/(100g min) (t = 2.230, d.f. = 16, P < 0.05), representing 20.9% and 10.8% reduction from baseline CBF during hyperventilation, respectively. Seizure interval decreased (i.e. frequency increased) with increasing magnitude of seizure focus CBF reduction during hyperventilation. Seizure interval was significantly correlated with epileptic temporal lobe CBF decrease during hyperventilation (R = 0.763, d.f. = 5, P < 0.05). The data suggest that, compared to nonepileptic brain, epileptic temporal lobe is particularly prone to hypoperfusion during hyperventilation. Epileptogenicity is a function of this seizure focus susceptibility to ischemia. The finding of abnormal seizure focus autoregulation during hyperventilation has implication for epileptic focus localization with cerebral blood flow analysis.

Original languageEnglish (US)
Pages (from-to)221-226
Number of pages6
JournalEpilepsy Research
Volume21
Issue number3
DOIs
StatePublished - 1995

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Cerebrovascular Circulation
Hyperventilation
Temporal Lobe
Seizures
Anticonvulsants
Homeostasis
Ischemia
Stroke
Brain

Keywords

  • Autoregulation
  • Cerebral blood flow
  • Epileptogenicity

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Pediatrics, Perinatology, and Child Health

Cite this

Response of human epileptic temporal lobe cortical blood flow to hyperventilation. / Weinand, Martin E; Philip Carter, L.; Oommen, Kalarickal J.; Hutzler, Ron; Labiner, David M; Talwar, Dinesh; El-Saadany, Waleed; Ahern, Geoffrey L.

In: Epilepsy Research, Vol. 21, No. 3, 1995, p. 221-226.

Research output: Contribution to journalArticle

Weinand, Martin E ; Philip Carter, L. ; Oommen, Kalarickal J. ; Hutzler, Ron ; Labiner, David M ; Talwar, Dinesh ; El-Saadany, Waleed ; Ahern, Geoffrey L. / Response of human epileptic temporal lobe cortical blood flow to hyperventilation. In: Epilepsy Research. 1995 ; Vol. 21, No. 3. pp. 221-226.
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