Response of malignant melanoma to plasma exchange, surgical debulking, and Corynebacterium parvum

J. C. Bottino, R. D. Rossen, Evan M Hersh, A. Rios, J. P. Hester, C. M. McBride

Research output: Contribution to journalArticle

Abstract

A 48 year old man with extensive cutaneous and subcutaneous metastatic malignant melanoma responded to treatment by repeated plasma exchanges, partial surgical debulking of tumor masses, and intravenous Corynebacterium parvum. Circulating immune complexes were measured by the serum C1(q) binding method. Tumor regression coincided with serum C1(q) binding reduction to normal levels. Clinical relapse was preceded by recurrent elevation of serum C1(q) binding activity.

Original languageEnglish (US)
Pages (from-to)53-57
Number of pages5
JournalInternational Journal of Artificial Organs
Volume1
Issue number1
StatePublished - 1978
Externally publishedYes

Fingerprint

Propionibacterium acnes
Plasma Exchange
Tumors
Melanoma
Plasmas
Antigen-Antibody Complex
Serum
Neoplasms
Recurrence
Skin
Therapeutics

ASJC Scopus subject areas

  • Biophysics

Cite this

Response of malignant melanoma to plasma exchange, surgical debulking, and Corynebacterium parvum. / Bottino, J. C.; Rossen, R. D.; Hersh, Evan M; Rios, A.; Hester, J. P.; McBride, C. M.

In: International Journal of Artificial Organs, Vol. 1, No. 1, 1978, p. 53-57.

Research output: Contribution to journalArticle

Bottino, J. C. ; Rossen, R. D. ; Hersh, Evan M ; Rios, A. ; Hester, J. P. ; McBride, C. M. / Response of malignant melanoma to plasma exchange, surgical debulking, and Corynebacterium parvum. In: International Journal of Artificial Organs. 1978 ; Vol. 1, No. 1. pp. 53-57.
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