Resting frontal EEG asymmetry as an endophenotype for depression risk: Sex-specific patterns of frontal brain asymmetry

Jennifer L. Stewart, Andrew W. Bismark, David N. Towers, James A. Coan, John J.B. Allen

Research output: Contribution to journalArticle

123 Scopus citations

Abstract

Resting frontal electroencephalographic (EEG) asymmetry has been hypothesized as a marker of risk for major depressive disorder (MDD), but the extant literature is based predominately on female samples. Resting frontal asymmetry was assessed on 4 occasions within a 2-week period in 306 individuals aged 18-34 (31% male) with (n = 143) and without (n = 163) lifetime MDD as defined by the Diagnostic and Statistical Manual of Mental Disorders, 4th edition (American Psychiatric Association, 1994). Lifetime MDD was linked to relatively less left frontal activity for both sexes using a current source density (CSD) reference, findings that were not accounted for solely by current MDD status or current depression severity, suggesting that CSD-referenced EEG asymmetry is a possible endophenotype for depression. In contrast, results for average and linked mastoid references were less consistent but demonstrated a link between less left frontal activity and current depression severity in women.

Original languageEnglish (US)
Pages (from-to)502-512
Number of pages11
JournalJournal of Abnormal Psychology
Volume119
Issue number3
DOIs
StatePublished - Aug 2010

Keywords

  • Depression
  • EEG asymmetry
  • Endophenotype
  • Sex differences

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Fingerprint Dive into the research topics of 'Resting frontal EEG asymmetry as an endophenotype for depression risk: Sex-specific patterns of frontal brain asymmetry'. Together they form a unique fingerprint.

  • Cite this