Rethinking data collection and signal processing. 1. Real-time oversampling filter for chemical measurements

Nicholas D. Laude, Christopher W. Atcherley, Michael L Heien

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Minimizing noise in chemical measurements is critical to achieve low limits of detection and accurate measurements. We describe a real-time oversampling filter that offers a method to reduce stochastic noise in a time-dependent chemical measurement. The power of this technique is demonstrated in its application to the separation of dopamine and serotonin by micellar electrokinetic chromatography with amperometric detection. Signal-to-noise ratios were increased by almost an order of magnitude, allowing for limits of detection of 100 and 120 amol, respectively. Real-time oversampling filters can be implemented using simple software algorithms and require no change to existing experimental apparatus. The application is not limited to analytical separations, and this technique can be used to improve the signal-to-noise ratio in any experiment where the necessary sampling rate is less than the maximum sampling rate of the analog-to-digital converter. Theory, implementation, and the performance of this filter are described. We propose that this technique should be the default mode of operation for an analog-to-digital converter.

Original languageEnglish (US)
Pages (from-to)8422-8426
Number of pages5
JournalAnalytical Chemistry
Volume84
Issue number19
DOIs
StatePublished - Oct 2 2012

Fingerprint

Signal processing
Digital to analog conversion
Signal to noise ratio
Sampling
Chromatography
Dopamine
Serotonin
Experiments

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

Rethinking data collection and signal processing. 1. Real-time oversampling filter for chemical measurements. / Laude, Nicholas D.; Atcherley, Christopher W.; Heien, Michael L.

In: Analytical Chemistry, Vol. 84, No. 19, 02.10.2012, p. 8422-8426.

Research output: Contribution to journalArticle

@article{7962ac52cb124508a3bb46e4ad712641,
title = "Rethinking data collection and signal processing. 1. Real-time oversampling filter for chemical measurements",
abstract = "Minimizing noise in chemical measurements is critical to achieve low limits of detection and accurate measurements. We describe a real-time oversampling filter that offers a method to reduce stochastic noise in a time-dependent chemical measurement. The power of this technique is demonstrated in its application to the separation of dopamine and serotonin by micellar electrokinetic chromatography with amperometric detection. Signal-to-noise ratios were increased by almost an order of magnitude, allowing for limits of detection of 100 and 120 amol, respectively. Real-time oversampling filters can be implemented using simple software algorithms and require no change to existing experimental apparatus. The application is not limited to analytical separations, and this technique can be used to improve the signal-to-noise ratio in any experiment where the necessary sampling rate is less than the maximum sampling rate of the analog-to-digital converter. Theory, implementation, and the performance of this filter are described. We propose that this technique should be the default mode of operation for an analog-to-digital converter.",
author = "Laude, {Nicholas D.} and Atcherley, {Christopher W.} and Heien, {Michael L}",
year = "2012",
month = "10",
day = "2",
doi = "10.1021/ac302169y",
language = "English (US)",
volume = "84",
pages = "8422--8426",
journal = "Analytical Chemistry",
issn = "0003-2700",
publisher = "American Chemical Society",
number = "19",

}

TY - JOUR

T1 - Rethinking data collection and signal processing. 1. Real-time oversampling filter for chemical measurements

AU - Laude, Nicholas D.

AU - Atcherley, Christopher W.

AU - Heien, Michael L

PY - 2012/10/2

Y1 - 2012/10/2

N2 - Minimizing noise in chemical measurements is critical to achieve low limits of detection and accurate measurements. We describe a real-time oversampling filter that offers a method to reduce stochastic noise in a time-dependent chemical measurement. The power of this technique is demonstrated in its application to the separation of dopamine and serotonin by micellar electrokinetic chromatography with amperometric detection. Signal-to-noise ratios were increased by almost an order of magnitude, allowing for limits of detection of 100 and 120 amol, respectively. Real-time oversampling filters can be implemented using simple software algorithms and require no change to existing experimental apparatus. The application is not limited to analytical separations, and this technique can be used to improve the signal-to-noise ratio in any experiment where the necessary sampling rate is less than the maximum sampling rate of the analog-to-digital converter. Theory, implementation, and the performance of this filter are described. We propose that this technique should be the default mode of operation for an analog-to-digital converter.

AB - Minimizing noise in chemical measurements is critical to achieve low limits of detection and accurate measurements. We describe a real-time oversampling filter that offers a method to reduce stochastic noise in a time-dependent chemical measurement. The power of this technique is demonstrated in its application to the separation of dopamine and serotonin by micellar electrokinetic chromatography with amperometric detection. Signal-to-noise ratios were increased by almost an order of magnitude, allowing for limits of detection of 100 and 120 amol, respectively. Real-time oversampling filters can be implemented using simple software algorithms and require no change to existing experimental apparatus. The application is not limited to analytical separations, and this technique can be used to improve the signal-to-noise ratio in any experiment where the necessary sampling rate is less than the maximum sampling rate of the analog-to-digital converter. Theory, implementation, and the performance of this filter are described. We propose that this technique should be the default mode of operation for an analog-to-digital converter.

UR - http://www.scopus.com/inward/record.url?scp=84867059011&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84867059011&partnerID=8YFLogxK

U2 - 10.1021/ac302169y

DO - 10.1021/ac302169y

M3 - Article

C2 - 22978644

AN - SCOPUS:84867059011

VL - 84

SP - 8422

EP - 8426

JO - Analytical Chemistry

JF - Analytical Chemistry

SN - 0003-2700

IS - 19

ER -