Retinal dynamics underlie its switch from inverse agonist to agonist during rhodopsin activation

Andrey V. Struts, Gilmar F.J. Salgado, Karina Martínez-Mayorga, Michael F. Brown

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

X-ray and magnetic resonance approaches, though central to studies of G protein-coupled receptor (GPCR)-mediated signaling, cannot address GPCR protein dynamics or plasticity. Here we show that solid-state 2H NMR relaxation elucidates picosecond-to-nanosecond-timescale motions of the retinal ligand that influence larger-scale functional dynamics of rhodopsin in membranes. We propose a multiscale activation mechanism whereby retinal initiates collective helix fluctuations in the meta I-meta II equilibrium on the microsecond-to-millisecond timescale.

Original languageEnglish (US)
Pages (from-to)392-394
Number of pages3
JournalNature Structural and Molecular Biology
Volume18
Issue number3
DOIs
StatePublished - Mar 1 2011

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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