Retinal venous oxygen saturation correlates with blood volume

Kurt R Denninghoff, Matthew H. Smith, Lloyd W. Hillman, David Redden, Loring W. Rue

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objectives: To evaluate the sensitivity of retinal venous O2 saturation (SrvO2) for early blood loss and reinfusion. A secondary objective was to measure the correlation between SrvO2 and mixed venous O2 saturation (SvO2) during blood loss and reinfusion. Methods: Seven anesthetized swine were bled at 0.8 mL/kg/min to 16 mL/kg. Shed blood was re-infused at the same rate and the swine were allowed to equilibrate. After equilibration, repeat hemorrhages were performed at 1.6 mL/kg/min and 2.4 mL/kg/mm. SrvO2 was measured using an eye oximeter (EOX) and SvO2 was measured using a fiber- optic catheter. Results: During blood loss, SrvO2 correlated with blood removed (r = -0.88, -0.97, -0.96) and SvO2 (r = 0.87, 0.98, 0.92). During reinfusion, SrvO2 correlated with blood re-infused (r = 0.63, 0.76, 0.82) and SvO2 (r = 0.80, 0.93, 0.96). SrvO2 decreased 1.22 ± 0.60%/mL/kg of blood removed. The rate of decrease in SrvO2 per minute (ΔSrvO2) when blood was removed at 2.4 mL/kg/min was significantly greater than ΔSrvO2 when blood was removed at 0.8 mL/kg/min (p < 0.007). The rates of change in blood pressure (BP) and pulse were not significantly different at any rate of blood removal. Conclusions: In this model, retinal venous O2 saturation correlated with blood volume and central venous O2 saturation. Unlike the rate of change in BP and heart rate, ΔSrvO2 values were significantly different at different rates of blood removal. Use of an EOX to monitor for blood loss, estimate the rate of hemorrhage, and evaluate the response to therapy during resuscitation warrants further study.

Original languageEnglish (US)
Pages (from-to)577-582
Number of pages6
JournalAcademic Emergency Medicine
Volume5
Issue number6
StatePublished - Jun 1998
Externally publishedYes

Fingerprint

Blood Volume
Oxygen
Swine
Hemorrhage
Blood Pressure
Resuscitation
Catheters
Heart Rate

Keywords

  • Blood loss
  • Noninvasive monitoring
  • Oxygen saturation
  • Retinal vessel
  • Shock
  • Swine

ASJC Scopus subject areas

  • Emergency Medicine

Cite this

Denninghoff, K. R., Smith, M. H., Hillman, L. W., Redden, D., & Rue, L. W. (1998). Retinal venous oxygen saturation correlates with blood volume. Academic Emergency Medicine, 5(6), 577-582.

Retinal venous oxygen saturation correlates with blood volume. / Denninghoff, Kurt R; Smith, Matthew H.; Hillman, Lloyd W.; Redden, David; Rue, Loring W.

In: Academic Emergency Medicine, Vol. 5, No. 6, 06.1998, p. 577-582.

Research output: Contribution to journalArticle

Denninghoff, KR, Smith, MH, Hillman, LW, Redden, D & Rue, LW 1998, 'Retinal venous oxygen saturation correlates with blood volume', Academic Emergency Medicine, vol. 5, no. 6, pp. 577-582.
Denninghoff KR, Smith MH, Hillman LW, Redden D, Rue LW. Retinal venous oxygen saturation correlates with blood volume. Academic Emergency Medicine. 1998 Jun;5(6):577-582.
Denninghoff, Kurt R ; Smith, Matthew H. ; Hillman, Lloyd W. ; Redden, David ; Rue, Loring W. / Retinal venous oxygen saturation correlates with blood volume. In: Academic Emergency Medicine. 1998 ; Vol. 5, No. 6. pp. 577-582.
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