Retraining speech production and fluency in non-fluent/agrammatic primary progressive aphasia

Maya L. Henry, H. Isabel Hubbard, Stephanie M. Grasso, Maria Luisa Mandelli, Stephen M Wilson, Mithra T. Sathishkumar, Julius Fridriksson, Wylin Daigle, Adam L. Boxer, Bruce L. Miller, Maria Luisa Gorno-Tempini

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The non-fluent/agrammatic variant of primary progressive aphasia (nfvPPA) presents with a gradual decline in grammar and motor speech resulting from selective degeneration of speech-language regions in the brain. There has been considerable progress in identifying treatment approaches to remediate language deficits in other primary progressive aphasia variants; however, interventions for the core deficits in nfvPPA have yet to be systematically investigated. Further, the neural mechanisms that support behavioural restitution in the context of neurodegeneration are not well understood. We examined the immediate and long-term benefits of video implemented script training for aphasia (VISTA) in 10 individuals with nfvPPA. The treatment approach involved repeated rehearsal of individualized scripts via structured treatment with a clinician as well as intensive home practice with an audiovisual model using 'speech entrainment'. We evaluated accuracy of script production as well as overall intelligibility and grammaticality for trained and untrained scripts. These measures and standardized test scores were collected at post-treatment and 3-, 6-, and 12-month follow-up visits. Treatment resulted in significant improvement in production of correct, intelligible scripted words for trained topics, a reduction in grammatical errors for trained topics, and an overall increase in intelligibility for trained as well as untrained topics at post-treatment. Follow-up testing revealed maintenance of gains for trained scripts up to 1 year post-treatment on the primary outcome measure. Performance on untrained scripts and standardized tests remained relatively stable during the follow-up period, indicating that treatment helped to stabilize speech and language despite disease progression. To identify neural predictors of responsiveness to intervention, we examined treatment effect sizes relative to grey matter volumes in regions of interest derived from a previously identified speech production network. Regions of significant atrophy within this network included bilateral inferior frontal cortices and supplementary motor area as well as left striatum. Volumes in a left middle/inferior temporal region of interest were significantly correlated with the magnitude of treatment effects. This region, which was relatively spared anatomically in nfvPPA patients, has been implicated in syntactic production as well as visuo-motor facilitation of speech. This is the first group study to document the benefits of behavioural intervention that targets both linguistic and motoric deficits in nfvPPA. Findings indicate that behavioural intervention may result in lasting and generalized improvement of communicative function in individuals with neurodegenerative disease and that the integrity of spared regions within the speech-language network may be an important predictor of treatment response.

Original languageEnglish (US)
Pages (from-to)1799-1814
Number of pages16
JournalBrain
Volume141
Issue number6
DOIs
StatePublished - Jun 1 2018
Externally publishedYes

Fingerprint

Primary Progressive Nonfluent Aphasia
Primary Progressive Aphasia
Language
Therapeutics
Aphasia
Motor Cortex
Frontal Lobe
Temporal Lobe
Linguistics
Neurodegenerative Diseases
Atrophy
Disease Progression

Keywords

  • agrammatic
  • non-fluent
  • primary progressive aphasia
  • treatment
  • voxel-based morphometry

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Henry, M. L., Hubbard, H. I., Grasso, S. M., Mandelli, M. L., Wilson, S. M., Sathishkumar, M. T., ... Gorno-Tempini, M. L. (2018). Retraining speech production and fluency in non-fluent/agrammatic primary progressive aphasia. Brain, 141(6), 1799-1814. https://doi.org/10.1093/brain/awy101

Retraining speech production and fluency in non-fluent/agrammatic primary progressive aphasia. / Henry, Maya L.; Hubbard, H. Isabel; Grasso, Stephanie M.; Mandelli, Maria Luisa; Wilson, Stephen M; Sathishkumar, Mithra T.; Fridriksson, Julius; Daigle, Wylin; Boxer, Adam L.; Miller, Bruce L.; Gorno-Tempini, Maria Luisa.

In: Brain, Vol. 141, No. 6, 01.06.2018, p. 1799-1814.

Research output: Contribution to journalArticle

Henry, ML, Hubbard, HI, Grasso, SM, Mandelli, ML, Wilson, SM, Sathishkumar, MT, Fridriksson, J, Daigle, W, Boxer, AL, Miller, BL & Gorno-Tempini, ML 2018, 'Retraining speech production and fluency in non-fluent/agrammatic primary progressive aphasia', Brain, vol. 141, no. 6, pp. 1799-1814. https://doi.org/10.1093/brain/awy101
Henry ML, Hubbard HI, Grasso SM, Mandelli ML, Wilson SM, Sathishkumar MT et al. Retraining speech production and fluency in non-fluent/agrammatic primary progressive aphasia. Brain. 2018 Jun 1;141(6):1799-1814. https://doi.org/10.1093/brain/awy101
Henry, Maya L. ; Hubbard, H. Isabel ; Grasso, Stephanie M. ; Mandelli, Maria Luisa ; Wilson, Stephen M ; Sathishkumar, Mithra T. ; Fridriksson, Julius ; Daigle, Wylin ; Boxer, Adam L. ; Miller, Bruce L. ; Gorno-Tempini, Maria Luisa. / Retraining speech production and fluency in non-fluent/agrammatic primary progressive aphasia. In: Brain. 2018 ; Vol. 141, No. 6. pp. 1799-1814.
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