Retrograde coronary blood flow during cardiopulmonary resuscitation in swine

Intracoronary Doppler evaluation

Karl B Kern, Ronald Hilwig, Gordon A. Ewy

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Cardiopulmonary resuscitation-generated coronary perfusion pressure and intracoronary flow velocity was studied with high-fidelity pressure transducers and an intracoronary Doppler catheter in 11 swine undergoing closed-chest manual cardiopulmonary resuscitation. Retrograde coronary blood flow in the mid left anterior descending coronary artery was documented during the compression (systolic) phase of chest compression. Techniques to enhance coronary perfusion pressure gradients, such as increasing the chest compression rate or increasing the force of compression, did not improve antegrade coronary blood flow velocity. Even when the aortic minus right atrial pressure gradient was raised throughout the cardiac cycle of closed-chest manual cardiopulmonary resuscitation, antegrade coronary flow occured only during the relaxation phase of chest compressions. This study indicates that coronary blood flow during ventricular fibrillation and closed-chest cardiopulmonary resuscitation occurs only during diastole or the release phase of chest compression and supports the use of diastolic coronary perfusion pressure as a reflection of myocardial blood flow during closed-chest manual cardiopulmonary resuscitation.

Original languageEnglish (US)
Pages (from-to)490-499
Number of pages10
JournalAmerican Heart Journal
Volume128
Issue number3
DOIs
StatePublished - 1994

Fingerprint

Cardiopulmonary Resuscitation
Swine
Thorax
Perfusion
Pressure
Pressure Transducers
Atrial Pressure
Diastole
Blood Flow Velocity
Ventricular Fibrillation
Coronary Vessels
Catheters

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Retrograde coronary blood flow during cardiopulmonary resuscitation in swine : Intracoronary Doppler evaluation. / Kern, Karl B; Hilwig, Ronald; Ewy, Gordon A.

In: American Heart Journal, Vol. 128, No. 3, 1994, p. 490-499.

Research output: Contribution to journalArticle

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