Reusable, polyethylene glycol-structured microfluidic channel for particle immunoassays

Jin Hee Han, Jeong Yeol Yoon

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

A microfluidic channel made entirely out of polyethylene glycol (PEG), not PEG coating to silicon or polydimethylsiloxane (PDMS) surface, was fabricated and tested for its reusability in particle immunoassays and passive protein fouling, at relatively high target concentrations (1 mg ml-1). The PEG devices were reusable up to ten times while the oxygen-plasma-treated polydimethyl siloxane (PDMS) device could be reused up to four times and plain PDMS were not reusable. Liquid was delivered spontaneously via capillary action and complicated bonding procedure was not necessary. The contact angle analysis revealed that the water contact angle on microchannel surface should be lower than ∼60°, which are comparable to those on dried protein films, to be reusable for particle immunoassays and passive protein fouling.

Original languageEnglish (US)
Article number6
JournalJournal of Biological Engineering
Volume3
DOIs
StatePublished - Apr 28 2009

ASJC Scopus subject areas

  • Environmental Engineering
  • Biomedical Engineering
  • Molecular Biology
  • Cell Biology

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