Reversible heterogeneous arterial phase liver perfusion associated with transient acute hepatitis: Findings on gadolinium-enhanced MRI

Diego R Martin, Donald Seibert, Ming Yang, Khalil Salman, Mathis P. Frick

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Purpose: To assess a possible correlation between active acute hepatitis and the development of abnormal liver perfusion demonstrated as heterogeneous enhancement on arterial phase gadolinium-enhanced MRI. Dynamically-enhanced MRI of the liver can detect reversible perfusion abnormalities that correlate with acute hepatitis. Materials and Methods: Six patients presenting with symptoms and clinical findings in keeping with transient acute hepatitis underwent serial MRI of the liver throughout the course of the disease. Serial liver enzyme analysis was performed for all six patients, and histopathology was assessed for three patients. Imaging included gadolinium-enhanced arterial and venous-phase gradient-echo sequences. Results: Arterial phase gadolinium-enhanced MRI showed abnormal irregular liver perfusion in the setting of acute hepatitis, and the degree of irregularity, as well as the persistence of irregular enhancement into the venous phase, correlated with the clinical severity of the disease. Conclusion: Acute hepatitis can cause irregular enhancement of the liver on arterial-phase, gadolinium-enhanced, gradient-echo MRI, a reversible finding that improves with clinical improvement of the disease.

Original languageEnglish (US)
Pages (from-to)838-842
Number of pages5
JournalJournal of Magnetic Resonance Imaging
Volume20
Issue number5
DOIs
StatePublished - Nov 2004
Externally publishedYes

Fingerprint

Gadolinium
Hepatitis
Perfusion
Liver
Enzymes

Keywords

  • Abdominal imaging
  • Acute hepatitis
  • Hepatitis
  • Liver
  • Liver enhancement
  • Liver MRI
  • Liver perfusion
  • MRI

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Reversible heterogeneous arterial phase liver perfusion associated with transient acute hepatitis : Findings on gadolinium-enhanced MRI. / Martin, Diego R; Seibert, Donald; Yang, Ming; Salman, Khalil; Frick, Mathis P.

In: Journal of Magnetic Resonance Imaging, Vol. 20, No. 5, 11.2004, p. 838-842.

Research output: Contribution to journalArticle

@article{be200cf3dc9749d99fca6d26da09b9a9,
title = "Reversible heterogeneous arterial phase liver perfusion associated with transient acute hepatitis: Findings on gadolinium-enhanced MRI",
abstract = "Purpose: To assess a possible correlation between active acute hepatitis and the development of abnormal liver perfusion demonstrated as heterogeneous enhancement on arterial phase gadolinium-enhanced MRI. Dynamically-enhanced MRI of the liver can detect reversible perfusion abnormalities that correlate with acute hepatitis. Materials and Methods: Six patients presenting with symptoms and clinical findings in keeping with transient acute hepatitis underwent serial MRI of the liver throughout the course of the disease. Serial liver enzyme analysis was performed for all six patients, and histopathology was assessed for three patients. Imaging included gadolinium-enhanced arterial and venous-phase gradient-echo sequences. Results: Arterial phase gadolinium-enhanced MRI showed abnormal irregular liver perfusion in the setting of acute hepatitis, and the degree of irregularity, as well as the persistence of irregular enhancement into the venous phase, correlated with the clinical severity of the disease. Conclusion: Acute hepatitis can cause irregular enhancement of the liver on arterial-phase, gadolinium-enhanced, gradient-echo MRI, a reversible finding that improves with clinical improvement of the disease.",
keywords = "Abdominal imaging, Acute hepatitis, Hepatitis, Liver, Liver enhancement, Liver MRI, Liver perfusion, MRI",
author = "Martin, {Diego R} and Donald Seibert and Ming Yang and Khalil Salman and Frick, {Mathis P.}",
year = "2004",
month = "11",
doi = "10.1002/jmri.20192",
language = "English (US)",
volume = "20",
pages = "838--842",
journal = "Journal of Magnetic Resonance Imaging",
issn = "1053-1807",
publisher = "John Wiley and Sons Inc.",
number = "5",

}

TY - JOUR

T1 - Reversible heterogeneous arterial phase liver perfusion associated with transient acute hepatitis

T2 - Findings on gadolinium-enhanced MRI

AU - Martin, Diego R

AU - Seibert, Donald

AU - Yang, Ming

AU - Salman, Khalil

AU - Frick, Mathis P.

PY - 2004/11

Y1 - 2004/11

N2 - Purpose: To assess a possible correlation between active acute hepatitis and the development of abnormal liver perfusion demonstrated as heterogeneous enhancement on arterial phase gadolinium-enhanced MRI. Dynamically-enhanced MRI of the liver can detect reversible perfusion abnormalities that correlate with acute hepatitis. Materials and Methods: Six patients presenting with symptoms and clinical findings in keeping with transient acute hepatitis underwent serial MRI of the liver throughout the course of the disease. Serial liver enzyme analysis was performed for all six patients, and histopathology was assessed for three patients. Imaging included gadolinium-enhanced arterial and venous-phase gradient-echo sequences. Results: Arterial phase gadolinium-enhanced MRI showed abnormal irregular liver perfusion in the setting of acute hepatitis, and the degree of irregularity, as well as the persistence of irregular enhancement into the venous phase, correlated with the clinical severity of the disease. Conclusion: Acute hepatitis can cause irregular enhancement of the liver on arterial-phase, gadolinium-enhanced, gradient-echo MRI, a reversible finding that improves with clinical improvement of the disease.

AB - Purpose: To assess a possible correlation between active acute hepatitis and the development of abnormal liver perfusion demonstrated as heterogeneous enhancement on arterial phase gadolinium-enhanced MRI. Dynamically-enhanced MRI of the liver can detect reversible perfusion abnormalities that correlate with acute hepatitis. Materials and Methods: Six patients presenting with symptoms and clinical findings in keeping with transient acute hepatitis underwent serial MRI of the liver throughout the course of the disease. Serial liver enzyme analysis was performed for all six patients, and histopathology was assessed for three patients. Imaging included gadolinium-enhanced arterial and venous-phase gradient-echo sequences. Results: Arterial phase gadolinium-enhanced MRI showed abnormal irregular liver perfusion in the setting of acute hepatitis, and the degree of irregularity, as well as the persistence of irregular enhancement into the venous phase, correlated with the clinical severity of the disease. Conclusion: Acute hepatitis can cause irregular enhancement of the liver on arterial-phase, gadolinium-enhanced, gradient-echo MRI, a reversible finding that improves with clinical improvement of the disease.

KW - Abdominal imaging

KW - Acute hepatitis

KW - Hepatitis

KW - Liver

KW - Liver enhancement

KW - Liver MRI

KW - Liver perfusion

KW - MRI

UR - http://www.scopus.com/inward/record.url?scp=7044220408&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=7044220408&partnerID=8YFLogxK

U2 - 10.1002/jmri.20192

DO - 10.1002/jmri.20192

M3 - Article

C2 - 15503331

AN - SCOPUS:7044220408

VL - 20

SP - 838

EP - 842

JO - Journal of Magnetic Resonance Imaging

JF - Journal of Magnetic Resonance Imaging

SN - 1053-1807

IS - 5

ER -