Reversing insect adaptation to transgenic insecticidal plants

Research output: Contribution to journalArticle

202 Citations (Scopus)

Abstract

The refuge-high-dose strategy for delaying insect adaptation to transgenic plants produces non-transgenic plants that enable survival of susceptible individuals. Previous theoretical work has suggested three requirements for success of the refuge-high-dose strategy: a low initial frequency of the resistance allele, extensive mating between resistant and susceptible adults and recessive inheritance of resistance. In order to understand an observed decrease in resistance frequency and improve the potential for managing resistance better, we used analytical and simulation models for exploring the conditions that prevent or reverse the evolution of resistance, even when resistance is not rare initially. Assuming random mating and recessive or nearly recessive inheritance of resistance, the factors favouring reversal of resistance are non-recessive costs of resistance, low initial resistance allele frequency, large refuges, incomplete resistance and density-independent population growth in refuges.

Original languageEnglish (US)
Pages (from-to)1475-1480
Number of pages6
JournalProceedings of the Royal Society B: Biological Sciences
Volume268
Issue number1475
DOIs
StatePublished - 2001

Fingerprint

pesticidal plants
transgenic plant
R Factors
Genetically Modified Plants
Gene Frequency
refuge
Insects
transgenic plants
inheritance (genetics)
insect
insects
random mating
Population Growth
dosage
gene frequency
Costs
population growth
simulation models
allele
alleles

Keywords

  • Bacillus thuringiensis
  • Fitness costs
  • Pesticide resistance
  • Refuge-high-dose strategy
  • Transgenic plants

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Agricultural and Biological Sciences (miscellaneous)

Cite this

Reversing insect adaptation to transgenic insecticidal plants. / Carriere, Yves; Tabashnik, Bruce E.

In: Proceedings of the Royal Society B: Biological Sciences, Vol. 268, No. 1475, 2001, p. 1475-1480.

Research output: Contribution to journalArticle

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