Review of the operational definition for first-episode psychosis

Nicholas Jk Breitborde, Vinod H. Srihari, Scott W. Woods

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

Aim: Given the growing interest in the study of first-episode psychosis, clinical and research programmes would benefit from a conceptual clarification of how to operationalize 'first-episode psychosis'. We review the variety of definitions in use and discuss their relative merits with respect to both clinical (e.g. early treatment) and research (e.g. obtaining meaningfully homogeneous populations) agendas. Methods: We completed a selective review of the literature to investigate how first-episode psychosis was operationally defined. Results: Operational definitions for 'first-episode psychosis' fall largely into three categories: (i) first treatment contact; (ii) duration of antipsychotic medication use; and (iii) duration of psychosis. Each definitional category contains a number of underlying assumptions that contribute to the strengths and weaknesses of the definition. Conclusions: The term 'first-episode psychosis' as used within clinical and research settings is misleading regardless of which operational definition is used. This term is typically used to refer to individuals early in the course of a psychotic illness or treatment rather than individuals who are truly in the midst of a first 'episode' of illness. The alternative of 'recent-onset psychosis' with related definitions based on 'duration of psychosis' is proposed. Based on this review, we provide suggestions with regard to the overarching pragmatic consideration of setting up a clinical service that can attract and assemble a population of early psychosis patients for the related purposes of treatment and research.

Original languageEnglish (US)
Pages (from-to)259-265
Number of pages7
JournalEarly Intervention in Psychiatry
Volume3
Issue number4
DOIs
StatePublished - Nov 2009

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Psychotic Disorders
Research
Therapeutics
Antipsychotic Agents
Population

Keywords

  • Definition
  • First-episode psychosis
  • Review

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Phychiatric Mental Health
  • Biological Psychiatry

Cite this

Review of the operational definition for first-episode psychosis. / Breitborde, Nicholas Jk; Srihari, Vinod H.; Woods, Scott W.

In: Early Intervention in Psychiatry, Vol. 3, No. 4, 11.2009, p. 259-265.

Research output: Contribution to journalArticle

Breitborde, Nicholas Jk ; Srihari, Vinod H. ; Woods, Scott W. / Review of the operational definition for first-episode psychosis. In: Early Intervention in Psychiatry. 2009 ; Vol. 3, No. 4. pp. 259-265.
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