Review on the systemic delivery of insulin via the ocular route

Yung Chi Lee, Pahala Simamora, Sirirat Pinsuwan, Samuel H. Yalkowsky

Research output: Contribution to journalReview article

35 Scopus citations

Abstract

Systemic drug absorption from the ocular route is well known. Although there is some absorption from the conjunctival sac, the nasal meatus is the site where the majority of systemic absorption of instilled drug takes place. This article reviews the principles of systemic absorption of insulin applied topically to the eye. The physiological and pharmaceutical considerations for formulation development and the strategy of improving the systemic absorption and bioavailability of insulin are also discussed.

Original languageEnglish (US)
Pages (from-to)1-18
Number of pages18
JournalInternational Journal of Pharmaceutics
Volume233
Issue number1-2
DOIs
StatePublished - Feb 21 2002

Keywords

  • Insulin
  • Ocular route
  • Systemic absorption

ASJC Scopus subject areas

  • Pharmaceutical Science

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