Right heart catheterization measuring central hemodynamics in cystic fibrosis during exercise

Don Hayes, Curt J. Daniels, Heidi M. Mansour, Benjamin T. Kopp, Andrew R. Yates, Karen S. McCoy, Alpa V. Patel, Stephen Kirkby

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Background Although pulmonary arterial hypertension (PAH) is a potential co-morbidity in cystic fibrosis (CF), right heart catheterization (RHC) is not commonly performed in this patient population until referral for lung transplantation. Material and methods An non-randomized observational pilot study was performed after an exercise protocol with an upright stationary bicycle was added to RHC performed in patients with CF undergoing evaluation for lung transplantation (LT). Results Twelve consecutive patients with advanced lung disease due to CF referred for LT completed RHC with exercise protocol. Transthoracic echocardiography (TTE) prior to the RHC did not identify evidence of PAH or significant structural abnormalities; right and left ventricular systolic function were normal. non-randomized RHC in this same cohort found 75% (9/12) had PAH with an elevation of the mean pulmonary artery pressure (PAP) at rest with a mean (±SD) of 27.8 ± 4.9 mmHg that significantly increased during exercise to 47.2 ± 5.4 mmHg, p = 0.0025. For the last 6 patients, pulmonary vascular resistance was calculated during exercise, with a significant increase from 3.15 ± 0.3 to 12.8 ± 0.6 Wood Units (p = 0.0313) comparing measurements at rest to exercise. Conclusion RHC at rest and during exercise was safely and effectively performed in patients with CF referred for LT. Furthermore, central hemodynamic measurements found significant worsening of PAH during exercise in a small cohort of CF patients with advanced lung disease.

Original languageEnglish (US)
Pages (from-to)1365-1369
Number of pages5
JournalRespiratory Medicine
Volume107
Issue number9
DOIs
StatePublished - Sep 2013

Keywords

  • Cystic fibrosis
  • Exercise
  • Pulmonary arterial hypertension
  • Right heart catheterization

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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    Hayes, D., Daniels, C. J., Mansour, H. M., Kopp, B. T., Yates, A. R., McCoy, K. S., Patel, A. V., & Kirkby, S. (2013). Right heart catheterization measuring central hemodynamics in cystic fibrosis during exercise. Respiratory Medicine, 107(9), 1365-1369. https://doi.org/10.1016/j.rmed.2013.02.020