Riser's reflux - An eye-opening experience

C. H. Poh, L. Allen, I. Malagon, A. Gasiorowska, T. Navarro-Rodriguez, J. Powers, B. Moty, M. R. Willis, Stuart F Quan, R. Fass

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background Patients with gastro-oesophageal reflux disease (GORD) commonly report waking up in the morning with a sour or bitter taste in their mouth. The aim of the study was to compare the prevalence and frequency of acid reflux events prior to and immediately after awakening from sleep in the morning between GORD patients and normal subjects. Methods Thirty-nine patients with heartburn at least three times a week and abnormal pH test and nine healthy controls were included. All subjects were evaluated by demographic and GORD Symptom Checklist questionnaires. Subjects underwent pH testing concomitantly with actigraphy. A novel technology that simultaneously integrates raw actigraphy and pH monitoring data was utilized to determine the presence, frequency, and characteristics of acid reflux events prior to (up to 1 h) and immediately after (10 and 20 min) awakening from sleep in the morning. Key Results Nineteen (48.7%) of the GORD patients had an acid reflux event within the first 20 min after awakening from sleep in the morning as compared to only seven (17.9%) during the hour prior to awakening. Within the first 10 and 20 min after awakening, patients had a total of 32 and 60 acid reflux events, respectively, as compared to 14 during the 1 h prior to awakening (P < 0.05). None of the healthy control patients demonstrated any reflux events during these three studied periods (P < 0.001). Conclusions & Inferences Riser's reflux is very common among GORD patients and possibly may explain reports of early-morning GORD symptoms.

Original languageEnglish (US)
Pages (from-to)387-394
Number of pages8
JournalNeurogastroenterology and Motility
Volume22
Issue number4
DOIs
StatePublished - Apr 2010

Fingerprint

Esophageal Diseases
Gastroesophageal Reflux
Actigraphy
Sleep
Acids
Teaching Rounds
Heartburn
Checklist
Mouth
Demography
Technology

Keywords

  • Actigraph
  • Awakening
  • Gastro-oesophageal reflux disease
  • PH testing
  • Sleep

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Gastroenterology
  • Physiology

Cite this

Poh, C. H., Allen, L., Malagon, I., Gasiorowska, A., Navarro-Rodriguez, T., Powers, J., ... Fass, R. (2010). Riser's reflux - An eye-opening experience. Neurogastroenterology and Motility, 22(4), 387-394. https://doi.org/10.1111/j.1365-2982.2009.01446.x

Riser's reflux - An eye-opening experience. / Poh, C. H.; Allen, L.; Malagon, I.; Gasiorowska, A.; Navarro-Rodriguez, T.; Powers, J.; Moty, B.; Willis, M. R.; Quan, Stuart F; Fass, R.

In: Neurogastroenterology and Motility, Vol. 22, No. 4, 04.2010, p. 387-394.

Research output: Contribution to journalArticle

Poh, CH, Allen, L, Malagon, I, Gasiorowska, A, Navarro-Rodriguez, T, Powers, J, Moty, B, Willis, MR, Quan, SF & Fass, R 2010, 'Riser's reflux - An eye-opening experience', Neurogastroenterology and Motility, vol. 22, no. 4, pp. 387-394. https://doi.org/10.1111/j.1365-2982.2009.01446.x
Poh CH, Allen L, Malagon I, Gasiorowska A, Navarro-Rodriguez T, Powers J et al. Riser's reflux - An eye-opening experience. Neurogastroenterology and Motility. 2010 Apr;22(4):387-394. https://doi.org/10.1111/j.1365-2982.2009.01446.x
Poh, C. H. ; Allen, L. ; Malagon, I. ; Gasiorowska, A. ; Navarro-Rodriguez, T. ; Powers, J. ; Moty, B. ; Willis, M. R. ; Quan, Stuart F ; Fass, R. / Riser's reflux - An eye-opening experience. In: Neurogastroenterology and Motility. 2010 ; Vol. 22, No. 4. pp. 387-394.
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