Risk factors associated with anemia, iron deficiency and iron deficiency anemia in rural Nepali pregnant women

Zeina Makhoul, Douglas L Taren, Burris R Duncan, Pooja Pandey, Cynthia Thomson, Joy Winzerling, Myra L Muramoto, Am Shrestha

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13 Citations (Scopus)

Abstract

We conducted a cross sectional study to investigate risk factors associated with severe anemia [hemoglobin (Hb) < 8.0 g dl -1] and poor iron status among Nepali pregnant women. Socio-demographic, anthropometric, health and dietary data were collected from 3,531 women living in the southeastern plains of Nepal. Stool samples were analyzed for intestinal helminthes. Dark adaptation was assessed using the Night Vision Threshold Test (NVTT). Hb levels were measured in all subjects to detect anemia and the soluble transferrin receptor (sTfR) was measured among a subsample of 479 women. The iron status categories were: 1) normal (Hb≥11.0 g/dl and sTfR≤8.5 mg/l); 2) anemia without iron deficiency (Hb<11.0 g/dl and sTfR≤8.5 mg/l); 3) iron deficiency without anemia (Hb≥11.0 g/dl and sTfR>8.5 mg/l); and 4) iron deficiency anemia (IDA): (Hb<11.0 g/dl and sTfR>8.5 mg/l). Factors associated with severe anemia and poor iron status were determined using logistic regression. Hookworm infection increased the risk for developing severe anemia [adjusted odds ratio (AOR): 4.26; 95% CI 1.67-10.89; p<0.01] and IDA [relative risk ratio (RRR): 2.18; 95% CI 1.14-4.16; p<0.05]. Impaired dark adaptation was a common risk factor for iron deficiency with and without anemia. Intake of iron supplements as tablets and/or tonic was protective against severe anemia, anemia without iron deficiency and IDA. Dietary heme iron was significantly associated with iron deficiency without anemia (RRR: 0.1; 95% CI 0.02-0.47; p<0.01). These results indicate the risk factors varied by classification and multiple approaches are needed to reduce anemia and associated nutrient deficiencies.

Original languageEnglish (US)
Pages (from-to)735-745
Number of pages11
JournalSoutheast Asian Journal of Tropical Medicine and Public Health
Volume43
Issue number3
StatePublished - 2012

Fingerprint

Iron-Deficiency Anemias
Anemia
Pregnant Women
Iron
Odds Ratio
Hookworm Infections
Dietary Iron
Dark Adaptation
Heme
Tablets
Hemoglobins
Cross-Sectional Studies
Logistic Models
Food

Keywords

  • Anemia
  • Iron deficiency
  • Nepal
  • Pregnant women

ASJC Scopus subject areas

  • Infectious Diseases
  • Public Health, Environmental and Occupational Health

Cite this

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title = "Risk factors associated with anemia, iron deficiency and iron deficiency anemia in rural Nepali pregnant women",
abstract = "We conducted a cross sectional study to investigate risk factors associated with severe anemia [hemoglobin (Hb) < 8.0 g dl -1] and poor iron status among Nepali pregnant women. Socio-demographic, anthropometric, health and dietary data were collected from 3,531 women living in the southeastern plains of Nepal. Stool samples were analyzed for intestinal helminthes. Dark adaptation was assessed using the Night Vision Threshold Test (NVTT). Hb levels were measured in all subjects to detect anemia and the soluble transferrin receptor (sTfR) was measured among a subsample of 479 women. The iron status categories were: 1) normal (Hb≥11.0 g/dl and sTfR≤8.5 mg/l); 2) anemia without iron deficiency (Hb<11.0 g/dl and sTfR≤8.5 mg/l); 3) iron deficiency without anemia (Hb≥11.0 g/dl and sTfR>8.5 mg/l); and 4) iron deficiency anemia (IDA): (Hb<11.0 g/dl and sTfR>8.5 mg/l). Factors associated with severe anemia and poor iron status were determined using logistic regression. Hookworm infection increased the risk for developing severe anemia [adjusted odds ratio (AOR): 4.26; 95{\%} CI 1.67-10.89; p<0.01] and IDA [relative risk ratio (RRR): 2.18; 95{\%} CI 1.14-4.16; p<0.05]. Impaired dark adaptation was a common risk factor for iron deficiency with and without anemia. Intake of iron supplements as tablets and/or tonic was protective against severe anemia, anemia without iron deficiency and IDA. Dietary heme iron was significantly associated with iron deficiency without anemia (RRR: 0.1; 95{\%} CI 0.02-0.47; p<0.01). These results indicate the risk factors varied by classification and multiple approaches are needed to reduce anemia and associated nutrient deficiencies.",
keywords = "Anemia, Iron deficiency, Nepal, Pregnant women",
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T1 - Risk factors associated with anemia, iron deficiency and iron deficiency anemia in rural Nepali pregnant women

AU - Makhoul, Zeina

AU - Taren, Douglas L

AU - Duncan, Burris R

AU - Pandey, Pooja

AU - Thomson, Cynthia

AU - Winzerling, Joy

AU - Muramoto, Myra L

AU - Shrestha, Am

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N2 - We conducted a cross sectional study to investigate risk factors associated with severe anemia [hemoglobin (Hb) < 8.0 g dl -1] and poor iron status among Nepali pregnant women. Socio-demographic, anthropometric, health and dietary data were collected from 3,531 women living in the southeastern plains of Nepal. Stool samples were analyzed for intestinal helminthes. Dark adaptation was assessed using the Night Vision Threshold Test (NVTT). Hb levels were measured in all subjects to detect anemia and the soluble transferrin receptor (sTfR) was measured among a subsample of 479 women. The iron status categories were: 1) normal (Hb≥11.0 g/dl and sTfR≤8.5 mg/l); 2) anemia without iron deficiency (Hb<11.0 g/dl and sTfR≤8.5 mg/l); 3) iron deficiency without anemia (Hb≥11.0 g/dl and sTfR>8.5 mg/l); and 4) iron deficiency anemia (IDA): (Hb<11.0 g/dl and sTfR>8.5 mg/l). Factors associated with severe anemia and poor iron status were determined using logistic regression. Hookworm infection increased the risk for developing severe anemia [adjusted odds ratio (AOR): 4.26; 95% CI 1.67-10.89; p<0.01] and IDA [relative risk ratio (RRR): 2.18; 95% CI 1.14-4.16; p<0.05]. Impaired dark adaptation was a common risk factor for iron deficiency with and without anemia. Intake of iron supplements as tablets and/or tonic was protective against severe anemia, anemia without iron deficiency and IDA. Dietary heme iron was significantly associated with iron deficiency without anemia (RRR: 0.1; 95% CI 0.02-0.47; p<0.01). These results indicate the risk factors varied by classification and multiple approaches are needed to reduce anemia and associated nutrient deficiencies.

AB - We conducted a cross sectional study to investigate risk factors associated with severe anemia [hemoglobin (Hb) < 8.0 g dl -1] and poor iron status among Nepali pregnant women. Socio-demographic, anthropometric, health and dietary data were collected from 3,531 women living in the southeastern plains of Nepal. Stool samples were analyzed for intestinal helminthes. Dark adaptation was assessed using the Night Vision Threshold Test (NVTT). Hb levels were measured in all subjects to detect anemia and the soluble transferrin receptor (sTfR) was measured among a subsample of 479 women. The iron status categories were: 1) normal (Hb≥11.0 g/dl and sTfR≤8.5 mg/l); 2) anemia without iron deficiency (Hb<11.0 g/dl and sTfR≤8.5 mg/l); 3) iron deficiency without anemia (Hb≥11.0 g/dl and sTfR>8.5 mg/l); and 4) iron deficiency anemia (IDA): (Hb<11.0 g/dl and sTfR>8.5 mg/l). Factors associated with severe anemia and poor iron status were determined using logistic regression. Hookworm infection increased the risk for developing severe anemia [adjusted odds ratio (AOR): 4.26; 95% CI 1.67-10.89; p<0.01] and IDA [relative risk ratio (RRR): 2.18; 95% CI 1.14-4.16; p<0.05]. Impaired dark adaptation was a common risk factor for iron deficiency with and without anemia. Intake of iron supplements as tablets and/or tonic was protective against severe anemia, anemia without iron deficiency and IDA. Dietary heme iron was significantly associated with iron deficiency without anemia (RRR: 0.1; 95% CI 0.02-0.47; p<0.01). These results indicate the risk factors varied by classification and multiple approaches are needed to reduce anemia and associated nutrient deficiencies.

KW - Anemia

KW - Iron deficiency

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KW - Pregnant women

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