Risk factors for intracerebral hemorrhage in a pooled prospective study

Jared D. Sturgeon, Aaron R. Folsom, W. T. Longstreth, Eyal Shahar, Wayne D. Rosamond, Mary Cushman

Research output: Contribution to journalArticle

199 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE - Few prospective studies have reported risk factors for intracerebral hemorrhage (ICH), and results are inconsistent. We studied risk factors for ICH in a pooled cohort of the Atherosclerosis Risk in Communities Study (ARIC) and the Cardiovascular Health Study (CHS). METHODS - The ARIC cohort was recruited in 1987 to 1989 and involves 15 792 men and women, aged 45 to 64 years at baseline, sampled from 4 US communities. The CHS cohort was recruited in 1989 to 1993 and involves 5888 men and women, aged 65 or over at baseline, sampled from 4 US communities. Baseline measurements included many potential vascular risk factors. The cohorts were followed for incident stroke events. RESULTS - Over 263 489 person-years of follow-up, 135 incident ICH events occurred. In a multivariable model, age, African-American ethnicity (versus Whites), and hypertension were positively associated with incident ICH, whereas low-density lipoprotein cholesterol and triglycerides were inversely related to incident ICH. Participants with systolic blood pressure ≥160 mm Hg or diastolic blood pressure ≥110 mm Hg had 5.55 (95% CI 3.07 to 10.0) times the rate of ICH as nonhypertensives. Sex, smoking, alcohol intake, body mass index, waist-to-hip ratio, waist circumference, and diabetes were not related to ICH. CONCLUSIONS - In this pooled cohort the risk factors for ICH were older age, African-American ethnicity, hypertension, lower LDL-C, and lower triglycerides.

Original languageEnglish (US)
Pages (from-to)2718-2725
Number of pages8
JournalStroke
Volume38
Issue number10
DOIs
StatePublished - Oct 2007

Fingerprint

Cerebral Hemorrhage
Prospective Studies
Blood Pressure
African Americans
Atherosclerosis
Cohort Studies
Hypertension
Waist-Hip Ratio
Health
Waist Circumference
LDL Cholesterol
Triglycerides
Body Mass Index
Smoking
Stroke
Alcohols

Keywords

  • Cerebral hemorrhage
  • Epidemiology
  • Hypertension
  • Risk factors
  • Stroke

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

Cite this

Sturgeon, J. D., Folsom, A. R., Longstreth, W. T., Shahar, E., Rosamond, W. D., & Cushman, M. (2007). Risk factors for intracerebral hemorrhage in a pooled prospective study. Stroke, 38(10), 2718-2725. https://doi.org/10.1161/STROKEAHA.107.487090

Risk factors for intracerebral hemorrhage in a pooled prospective study. / Sturgeon, Jared D.; Folsom, Aaron R.; Longstreth, W. T.; Shahar, Eyal; Rosamond, Wayne D.; Cushman, Mary.

In: Stroke, Vol. 38, No. 10, 10.2007, p. 2718-2725.

Research output: Contribution to journalArticle

Sturgeon, JD, Folsom, AR, Longstreth, WT, Shahar, E, Rosamond, WD & Cushman, M 2007, 'Risk factors for intracerebral hemorrhage in a pooled prospective study', Stroke, vol. 38, no. 10, pp. 2718-2725. https://doi.org/10.1161/STROKEAHA.107.487090
Sturgeon JD, Folsom AR, Longstreth WT, Shahar E, Rosamond WD, Cushman M. Risk factors for intracerebral hemorrhage in a pooled prospective study. Stroke. 2007 Oct;38(10):2718-2725. https://doi.org/10.1161/STROKEAHA.107.487090
Sturgeon, Jared D. ; Folsom, Aaron R. ; Longstreth, W. T. ; Shahar, Eyal ; Rosamond, Wayne D. ; Cushman, Mary. / Risk factors for intracerebral hemorrhage in a pooled prospective study. In: Stroke. 2007 ; Vol. 38, No. 10. pp. 2718-2725.
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AB - BACKGROUND AND PURPOSE - Few prospective studies have reported risk factors for intracerebral hemorrhage (ICH), and results are inconsistent. We studied risk factors for ICH in a pooled cohort of the Atherosclerosis Risk in Communities Study (ARIC) and the Cardiovascular Health Study (CHS). METHODS - The ARIC cohort was recruited in 1987 to 1989 and involves 15 792 men and women, aged 45 to 64 years at baseline, sampled from 4 US communities. The CHS cohort was recruited in 1989 to 1993 and involves 5888 men and women, aged 65 or over at baseline, sampled from 4 US communities. Baseline measurements included many potential vascular risk factors. The cohorts were followed for incident stroke events. RESULTS - Over 263 489 person-years of follow-up, 135 incident ICH events occurred. In a multivariable model, age, African-American ethnicity (versus Whites), and hypertension were positively associated with incident ICH, whereas low-density lipoprotein cholesterol and triglycerides were inversely related to incident ICH. Participants with systolic blood pressure ≥160 mm Hg or diastolic blood pressure ≥110 mm Hg had 5.55 (95% CI 3.07 to 10.0) times the rate of ICH as nonhypertensives. Sex, smoking, alcohol intake, body mass index, waist-to-hip ratio, waist circumference, and diabetes were not related to ICH. CONCLUSIONS - In this pooled cohort the risk factors for ICH were older age, African-American ethnicity, hypertension, lower LDL-C, and lower triglycerides.

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